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AssigneeThe Kitasato Institute
InventorsSatoshi Omura, Hiroshi Tomoda, Yoko Takahashi, Yutaka Ebizuka, Masaaki Shibuya
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The present invention comprising culturing a microorganism which belongs to genus Streptomyces and has ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in a medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid, and isolating K99-5041-C1x substance and/or K99-5041-C2x substance form the cultured mass. Since the obtained K99-5041-C1x substance and/or K99-5041-C2x substance exhibit inhibitory activity against lanosterol synthase, these substances are expected to apply clinically for preventive and therapeutic agents caused by accumulation of cholesterol in humans and antifungal agents.
K99-5041-C1x substance represented by the following formula [I]:
K99-5041-C2x substance represented by the following formula [II]:
A composition of K99-5041 substance comprising especially K99-5041-C1x substance represented by the following formula [I]:
A process for production of K99-5041-C1x substance comprising culturing a microorganism belonging to genus Streptomyces and having ability to produce K99-5041-C1x substance in a medium, accumulating K99-5041-C1x substance in a culture fluid and isolating K99-5041-C1x substance from the cultured mass.
A process for production of K99-5041-C2x substance comprising culturing a microorganism belonging to genus Streptomyces and having ability to produce K99-5041-C2x substance in a medium, accumulating K99-5041-C2x substance in a culture fluid and isolating K99-5041-C2x substance from the cultured mass.
The process for production of a composition of K99-5041 substance comprising culturing the microorganism belonging to genus Streptomyces having ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in the medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid and isolating K99-5041-C1x substance and/or K99-5041-C2x substance from the cultured mass.
A microorganism which is Streptomyces sp K99-5041 FERM BP-8272.
Dependencies are inferred from the claim text.