Composition for the prevention and/or treatment in newborn babies of the effects of complications during childbirth
AssigneeUniversitair Medisch Centrum
InventorsCacha Marie Petronelle Catherine Dorothee Peeters, Floris Groenendaal, Frank Van Bel
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Abstract
A selective inhibitor of neuronal nitric oxide synthase (nNOS) and of inducible nitric oxide synthase (iNOS), which does not substantially inhibit endothelial nitric oxide synthase (eNOS), can be effectively used for the treatment, in human or other mammalian neonates, of the effects of complications during childbirth. Such effects include perinatal asphyxia and hypoxia-ischemia. A very useful example of such a selective inhibitor is 2-iminobiotin.
Claims4
Use of 2-iminobiotin as a neuronal nitric oxide synthase inhibitor and an inducible nitric oxide synthase inhibitor but not an endothelial nitric oxide synthase inhibitor, in the preparation of a pharmaceutical composition for the prevention and/or treatment, in human or other mammalian neonates, of the effects of perinatal asphyxia.
Dependencies are inferred from the claim text.