Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof

An NF-kappa B activation inhibitor, an inflammatory cytokine production inhibitor, a matrix metalloprotease production inhibitor or an inflammatory cell adhesion factor expression inhibitor comprising, as the active ingredient, a cyclopropanecarboxylic acid amide compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof:

• 26
• wherein R1 and R2 may be the same or different and each represents an alkyl group or a halogen atom;
• R3 represents a hydrogen atom or an alkyl group;
• A represents an aromatic ring or a heterocyclic ring;
• R4 and R5 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, an alkyl group having a substituent(s), an aryl group, an aryl group having a substituent(s), a mercapto group, an alkoxy group, an alkylthio group, an acyl group, an acyloxy group, an amino group, an alkylamino group, an amino protecting group-substituted amino group, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, a nitro group, a trifluoromethyl group or a cyano group;
• X represents a hydrogen atom, a hydroxyl group, an alkyl group having a substituent(s), an aryl group, an aryl group having a substituent(s), a mercapto group, an alkoxy group, an alkylthio group, an acyl group, an acyloxy group, an amino group, an alkylamino group, an amino protecting group-substituted amino group, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, a nitro group, a trifluoromethyl group, a cyano group or a group represented by the following general formula (II):
• 27
• wherein —Y— represents an atomic bond, —O—, —CR8R9—, —CO—, —NR10—, —S—, —SO—, —SO2—, —O—CO—, —CO—O—, —CO—NR11—, —NR12—CO—, —SO2—, —NR13—, —NR14—SO2—, —CR15═CR16—, —CR17R18—CR19R20— (wherein R8, R9, R15, R16, R17, R18, R19 and R20 each represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, an alkyl group having a substituent(s), a mercapto group, an alkoxy group, an alkylthio group, an acyl group, an acyloxy group, an amino group, an alkylamino group, an amino protecting group-substituted amino group, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group or a cyano group;
• and R10, R11, R12, R13 and R14 each represents a hydrogen atom or an alkyl group);
• B represents an aromatic ring or a heterocyclic ring;
• R6 and R7 may be the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group, an alkyl group having a substituent(s), an aryl group, an aryl group having a substituent(s), a hydroxyl group, a mercapto group, an alkoxy group, an alkylthio group, an acyl group, an acyloxy group, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, a nitro group, a trifluoromethyl group or a cyano group, provided that either R6 or R7 may be linked with A to form a ring].