Novel pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators

A compound of formula I:

• 102
• a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a derivative thereof, or a prodrug thereof, wherein:
• R1 is selected from —H, —NR7R8, —OR7, —S(O)mR7, —C(O)R7, —C(S)R7, C(O)OR7, —C(S)OR7, —C(O)NR7R8, —C(S)NR7R8, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, and substituted heterocycloalkyl;
• R2 is selected from —NR7R8, —OR7, —S(O)mR7, —C(O)R7, C(S)R7, —C(O)OR7, —C(S)OR7, —C(O)NR7R8, —C(S)NR7R8, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, Ar, aryl cycloalkyl, substituted aryl cycloalkyl, heteroaryl cycloalkyl, substituted heteroaryl cycloalkyl, aryl heterocycloalkyl, substituted aryl heterocycloalkyl, heteroaryl heterocycloalkyl, substituted heteroaryl heterocycloalkyl, —NHC(O)alkyl, —NHC(S)alkyl, —NHC(O)aryl, —NHC(S)aryl, —NHC(O)OR7, —NHC(O)SR7, —NHC(S)OR7, —NHC(O)NR7R8, —NHC(S)NR7R8, —NHS(O),alkyl, —NHS(O),aryl, —NHS(O), NR7R8,
• 103
• R3, R4 and R5 can be the same or different and are independently selected from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, Ar, halogen, —NR9R10, —OR9, —S(O)mR9, —C(O)R9, —C(S)R9, —C(O)OR9, —C(S)OR9, —C(O)NR9R°, and —C(S)NR9R10;
• R6 is selected from Ar, —OAr, —S(O)mAr, —N(H)Ar, and —NR11R12;
• R7 and R8 (1) can be the same or different and are independently selected from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, Ar, or (2) when both R7 and R8 are alkyls and attached to a nitrogen, may form, along with the nitrogen, a 3-8 membered mono heterocyclic ring, which may be optionally substituted with 1 to 3 substituents selected from halogen, —R9, —OR9, —S(O)mR9, —NR9R10, —C(O)R9, —C(S)R9, —CN, —C(O)NR9R10, —C(S)NR9R10, —NR9C(O)R10, —NR9C(S)R10, —S(O),NR9R10, —NR9S(O),R10, —NO2, —C(O)OR9 and —C(S)OR9, or (3) when R7 and R8 are attached to a nitrogen and R7 is alkyl and R8 is either cycloalkyl or Ar, form a 7-12 membered bicyclic heterocyclic ring, which may be optionally substituted with 1 to 3 substituents selected from halogen, —R9, —OR9, —S(O)mR9, —NR9R10, —C(O)R9, —C(S)R9, —CN, —C(O)NR9R10, —C(S)NR9R10, —NR9C(O)R10, —NR9C(S)R0, —S(O)nNR9R0, —NR9S(O)nR10, —NO2, —C(O)OR9 and —C(S)OR9;
• R9 and R10 can be the same or different and are independently selected from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, and Ar;
• R11 and R12 (1) can be the same or different and are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, Ar, or (2) can form a 5- or 6-membered monocylic or a 8-10-membered bicyclic heteroaryl ring system, which may optionally contain, in addition to the nitrogen, an additional heteroatom selected from N, S, and O, and which may optionally have an oxo substituent on the ring and also may be optionally substituted with 1 to 3 substituents selected from halogen, —R9, —OR9, S(O)mR9—NR9R10, —C(O)R9, —C(S)R9, —CN, —C(O)NR9R10, —C(S)NR9R10, —NR9C(O)R10, —NR9C(S)R0, —S(O)nNR9R10, —NR9S(O),R10, —NO2, —C(O)OR9 and —C(S)OR9;
• m is 0, 1 or 2;
• and
• n is 1 or 2.