US 2004/0002505 A1 · Medicinal compositions for cocominant use as anticancer agent

Abstract

The present invention provides a medicinal composition having an excellent antitumor activity. That is, it provides a medicinal composition comprising a sulfonamide compound, a sulfonate compound or a salt of them, which is represented by the following formula: 1 wherein ring A represents an aromatic ring which may have a substituent group; ring B represents a 6-membered unsaturated hydrocarbon ring which may have a substituent group etc.; ring C represents a 5-membered hetero-ring containing one or two nitrogen atoms, and the ring C may have a substituent group; W represents a single bond or —CH═CH—; X represents —NH— etc.; and Y represents a carbon atom or a nitrogen atom; and Z represents —NH— etc.), particularly N-(3-chloro-1H-indol-7-yl) -4-sulfamoylbenzenesulfonamide or a salt thereof, combined with at least one substance selected from (1) irinotecan hydrochloride trihydrate; (2) mitomycin C; (3) 5-fluorouracil; (4) cisplatin; (5) gemcitabinehydrochloride; (6) doxorubicin; (7) taxol; and (8) a salt of the above-mentioned (1) to (7).

Claims24

Dependent claims

A medicinal composition comprising a sulfonamide compound, a sulfonate compound or a salt of them (sulfone compound (I)), which is represented by the following formula:

12
(wherein ring A represents a monocyclic aromatic ring or a bicyclic aromatic ring, each of which may have a substituent group;
ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated hetero-ring containing one nitrogen atom, each of which may have a substituent group;
ring C represents a 5-membered hetero-ring containing one or two nitrogen atoms, and the ring C may have a substituent group;
W represents a single bond or —CH═CH—;
X represents —N(R1)— (wherein R1 represents a hydrogen atom or a lower alkyl group) or an oxygen atom;
Y represents a carbon atom or a nitrogen atom;
Z represents —N(R2)—(R2 represents a hydrogen atom or a lower alkyl group) or a nitrogen atom, provided that the above-defined compounds exclude compounds in the following cases (a) and (b):
(a) ring A is 4-methylbenzene;
W is a single bond;
X is —NH—;
ring B ismethoxybenzene;
and ring C is unsubstituted imidazole;
and (b) ring A is 4-(acetamide)benzene or 4-aminobenzene;
W is a single bond;
X is —NH—;
ring B is unsubstituted benzene;
and ring C is unsubstituted pyrazole), combined with and at least one substance (III) selected from (1) irinotecan hydrochloride trihydrate;
(2) mitomycin C;
(3) 5-fluorouracil;
(4) cisplatin;
(5) gemcitabine hydrochloride;
(6) doxorubicin;
(7) taxol;
and (8) a salt of the above-mentioned (1) to (7).

22 more elements

Dependencies are inferred from the claim text.

Medicinal compositions for cocominant use as anticancer agent

Life of this patent

Medicinal compositions for cocominant use as anticancer agent

Life of this patent

Abstract

Claims24