Orally active salts with tyrosine kinase activity
AssigneeMerck & Co., Inc.
InventorsMark E. Fraley, Shyam B. Karki, Yuntae Kim
Life of this patent
Estimating the term…
Abstract
The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
Claims39
A mesylate salt 3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one.
A chloride salt 3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one.
A mesylate salt of 3-[5-(4-methyl-5-oxo-[1,4]diazepan-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one.
A chloride salt of 3-[5-(4-methyl-5-oxo-[1,4]diazepan-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one.
A mesylate salt of 3-{5-[4-(2-hydroxy-ethanoyl)-piperazin-1-ylmethyl]-1H-indol-2-yl }-1H-quinolin-2-one.
A chloride salt of 3-{5-[4-(2-hydroxy-ethanoyl)-piperazin-1-ylmethyl]-1H-indol-2-yl }-1H-quinolin-2-one.
A mesylate salt of 3-(5-{2-[(2-methoxyethyl)(methyl) amino]ethoxy)}-1H-indol-2-yl)quinolin-2(1H)-one.
A mesylate or chloride salt of 3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one;
- 3-[5-(4-methyl-5-oxo-[1,4]diazepan-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one;
- 3-{5-[4-(2-hydroxy-ethanoyl)-piperazin-1-ylmethyl]-1H-indol-2-yl}-1H-quinolin-2-one;
- or 3-(5-{2-[(2-methoxyethyl)(methyl) amino]ethoxy }-1H-indol-2-yl)quinolin-2( 1H)-one.
Dependencies are inferred from the claim text.