Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade

A compound having the structure:

• 96
• wherein
• X1, X2, X3, X4, X5, and X6 are each ring atoms defining a 6-membered heterocyclic ring;
• X1 and X4 are independently carbon or nitrogen;
• X2 is nitrogen;
• X3 is carbon;
• X5 and X6 are independently carbon, nitrogen, oxygen or sulfur;
• L1, L3 and L4 are linkages through which Z1, Z3, and Z4, respectively, are covalently bonded to different ring atoms of the 6-membered heterocyclic ring defined by X1, X2, X3, X4, X5, and X6, wherein Z1 is covalently bonded to X1, Z3 is covalently bonded to X3, and Z4 is covalently bonded to X4, each of L1, L3 and L4 independently being a covalent bond or comprising one or more atoms through which Z1, Z3, and Z4 are covalently bonded to X1, X3 and X4, respectively;
• Z1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl;
• Z3 is a substituted hydrocarbyl, or a 5- or 6-membered substituted heterocyclic or aromatic ring, the substituents of the hydrocarbyl or ring comprising an amidino, guanidino, amino, or aminoalkyl group, the ring atoms of the 5- or 6-membered heterocyclic or aromatic ring of Z3 being carbon, sulfur, nitrogen, or oxygen, wherein the 5- or 6-membered ring is optionally substituted at any position with halogen, hydroxy, or alkyl;
• and
• Z4 comprises hydrocarbyl, substituted hydrocarbyl or a 5- or 6-membered heterocyclic ring, the ring atoms of the 5- or 6-membered heterocyclic ring being carbon, sulfur, nitrogen or oxygen.