ATM inhibitors

A compound of formula I:

• 210
• and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein:
• one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group;
• Y is either O or S;
• R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms;
• R3 is a phenyl or pyridyl group, attached by a first bridge group selected from —S—, —S(═O)—, —S(═O)2—, —O—, —NRN— and CRC1RC2— to an optionally substituted C5-20 carboaryl group, in which one aromatic ring atom may be replaced by a nitrogen ring atom;
• the phenyl or pyridyl group and optionally substituted C5-20 carboaryl group being optionally further linked by a second bridge group, which is bound adjacent the first bridge group on both groups so as to form an optionally substituted C5-7 ring fused to both the phenyl or pyridyl group and the C5-20 carboaryl group, the phenyl or pyridyl group being further optionally substituted;
• wherein RN is selected from hydrogen, an ester group, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group and an optionally substituted C5-20 aryl group;
• and RC1 and RC2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group and an optionally substituted C5-20 aryl group.