Antisense oligonucleotides against VR1
AssigneeGruenenthal GmbH
InventorsJens Kurreck, Volker A. Erdmann
Life of this patent
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Abstract
Antisense oligodeoxynucleotides against VR1, corresponding nucleotide constructs, cells containing said nucleotide constructs, pharmaceutical and diagnostic substances, uses thereof in pain therapy, and methods for diagnosing symptoms related to VR1 and for identifying pain-modulating substances.
Claims58
An oligonucleotide comprising a base sequence according to one of sequences (b) to (j) in FIG. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16, wherein each of sequences (b) to (j) comprises a sequence domain shown in sequence (a) in the respective Figures.
An oligonucleotide according to claim 2, comprising
- (1) a base sequence according to sequence (k) in each of the FIG. 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16;
- or
- (2) a sequence differing from (1) by at most two bases not located in the sequence domain shown in sequence (a).
A polynucleotide construct comprising, in two separate domains, Fragment I and Fragment III according to sequence (l), (m), or (n);
- or helix I and helix III according to sequences (o), (p) or (q), in FIG. 1, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13 or 15.
Dependencies are inferred from the claim text.