Human nucleic acid sequences which are overexpressed in normal pancreas tissue
AssigneeMetagen Gesellschaft Fur Genomforschung MBH
InventorsThomas Specht, Bernd Hinzmann, Armin Schmitt, Christian Pilarsky, Edgar Dahl, Andre Rosenthal
Life of this patent
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Abstract
Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from normal pancreatic tissue, which code for gene products or portions thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.
Claims38
A nucleic acid sequence that codes a gene product or a portion thereof, comprising
- a) a nucleic acid sequence, selected from the group Seq. Id nos. 14, 24, 25, 27-31, 35-37 and 67,
- b) an allelic variation of the nucleic acid sequences named under a)
- or
- c) a nucleic acid sequence that is complementary to the nucleic acid sequences named under a) or b):
A nucleic acid sequence according to one of the sequences Seq. ID Nos. 14, 24, 25, 27-31, 35-37, 67 or a complementary or allelic variant thereof.
Nucleic acid sequence Seq. ID Nos. 2-37 and 67, characterized in that it is expressed elevated in normal pancreatic tissue.
BAC, PAC and cosmid clones containing functional genes and their chromosomal localization according to sequences Seq. ID Nos. 2-37 and 67 for use as vehicles for gene transfer.
Polypeptide partial sequences according to sequences Seq. ID Nos. 39-63 and 68-71.
Use of polypeptide partial sequences according to sequences Seq. ID Nos. 39-63 and 68-71 as tools for finding active ingredients against pancreatic tumors.
Use of nucleic acid sequences according to sequences Seq. ID Nos. 2-37 and 67 for expression of polypeptides that can be used as tools for finding active ingredients against pancreatic tumors.
Use of nucleic acid sequences Seq. ID Nos. 2-37 and 67 in sense or antisense form.
Use of polypeptide partial sequences Seq. ID Nos. 39-63 and 68-71 as pharmaceutical agents in gene therapy for treatment of pancreatic tumors.
Use of polypeptide partial sequences Seq. ID Nos. 39-63 and 68-71 for the production of a pharmaceutical agent for treatment of pancreatic tumors.
Pharmaceutical agent, containing at least one polypeptide partial sequence Seq. ID Nos. 39-63 and 68-71.
Genomic genes, their promoters, enhancers, silencers, exon structure, intron structure and their splice variants, that can be obtained from cDNAs of sequences Seq. ID Nos. 2-37 and 67.
Dependencies are inferred from the claim text.