Combination therapy for effecting weight loss and treating obesity
AssigneeVivus, Inc.
InventorThomas Najarian
Life of this patent
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Abstract
The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination with an anticonvulsant sulfamate derivative (e.g., topiramate) such that the subject experiences weight loss. The combination methods of the present invention also are effective against symptoms associated with Syndrome X. The invention also features pharmaceutical compositions and kits for use in the practice of these novel therapies.
Claims33
A method for effecting weight loss in a subject comprising administering a daily dose of topiramate in the range of about 100 to 250 mg and a daily dose of phentermine in the range of about 5 to 15 mg.
A method of treating a subject with Syndrome X, comprising administering to the subject a daily dose of topiramate in the range of about 100 to 250 mg and a daily dose of phentermine in the range of about 5 to 15 mg, such that at least one symptom of Syndrome X is effectively treated.
A method of treating at least one side effect associated with obesity comprising administering to an obese subject a daily dose of topiramate in the range of about 100 to 250 mg and a daily dose of phentermine in the range of about 5 to 15 mg, such that at least one side effect associated with obesity is effectively treated.
A pharmaceutical composition comprising about 100 mg to 250 mg topiramate and about 5 mg to 15 mg phentermine.
A kit comprising a packaged combination of phentermine and topiramate, and instructions for a patient to carry out drug administration to achieve weight loss, wherein the phentermine and topiramate are present in separate and discrete dosage forms, and further wherein the phentermine dosage forms each contain about 5 mg to about 15 mg phentermine and the topiramate dosage forms each contain about 100 to 250 mg topiramate.
Dependencies are inferred from the claim text.