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OwnerAra V. Hovanessian, Jean-Paul Briandinventors
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Peptides that are involved in the attachment of a microorganism or a protein ligand to the cell membrane are provided. The peptides comprise one RGG domain of a cell-surface expressed protein. These peptides include peptides from nucleolin, specifically the C-terminal portion, and more specifically the last 63 amino acids of the C-terminal portion. These peptides can inhibit binding of viruses, such as HIV, to the cell membrane. Also provided is a therapeutic composition of these peptides and a method of treating an infection by a micrioorganism using these peptides.
A purified peptide wherein said peptide comprises one RGG domain of a cell-surface-expressed protein, or a fragment thereof, involved in the attachment of a microorganism or a protein ligand to the membrane of said cell.
A purified polynucleotide wherein said polynucleotide codes for the peptide of SEQ ID NO:
A therapeutic composition for preventing or treating a virus infection wherein said composition comprises a peptide comprising one RGG domain of a cell-surface-expressed protein, or a fragment thereof, involved in a microorganism infection, or a biologically active derivative thereof, along with a pharmaceutically acceptable carrier.
A purified polynucleotide wherein said polynucleotide is SEQ ID NO:
An antibody, wherein the antibody is raised against NP63 or an NP63 analogue, binds to the C-terminal tail of surface nucleolin, and blocks HIV infection.
Dependencies are inferred from the claim text.