Targeted immunogens
AssigneesAventis Pasteur Limited, Aventis Pharmaceuticals Inc.
InventorsRobert Adam Uger, Danielle Salha, Brian Barber, Clarence C. Morse, Yong Guo, Su Cheng
Life of this patent
Estimating the term…
Abstract
The present invention provides reagents and methods for producing and utilizing targeted immunogens. In preferred embodiments, an immunogen is conjugated to an amino acid sequence that targets the immunogen to the MHC presentation pathway. Using the reagents and methods provided herein, immunization protocols may be enhanced resulting in increased immunity of the host.
Claims45
A polypeptide consisting essentially of a first amino acid sequence comprising a comprising a transduction sequence of hPER1 linked to a second amino acid sequence comprising a cytotoxic T lymphocyte epitope.
A polypeptide of 1 wherein the first amino acid sequence is SRRHHCRSKAKRSRHH or GRRHHRRSKAKRSR.
A method for immunizing a host comprising admixing a polypeptide or composition of 1 with dendritic cells to generate peptide-loaded dendritic cells and administering the peptide-loaded dendritic cells to the host.
An isolated recombinant DNA molecule comprising a first DNA sequence encoding a cytotoxic T lymphocyte epitope and a second DNA sequence encoding a transduction sequence of hPER1.
Dependencies are inferred from the claim text.