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US 2004/0002447 A1Published application
Induction of insulin expression
AssigneeThe Regents of the University of California
InventorsFred Levine, Pamela Itkin-Ansari
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Abstract
The present invention provides compositions and methods for inducing insulin expression in cells by contacting the cells with a histone deacetylase inhibitor.
Claims44
A method for inducing insulin gene expression in cells, the method comprising the steps of:
- (i) providing a cell that expresses a PDX-1 polynucleotide;
- and
- (ii) contacting the cell with a histone deacetylase inhibitor, thereby inducing insulin gene expression in the cells.
A method of identifying a compound that modulates β-cell function, the method comprising the steps of contacting a cell with a compound in the presence of a histone deactylase inhibitor, wherein the cell expresses a PDX-1 polynucleotide;
- and
- determining the effect of the compound on β-cell function.
A culture of cells expressing PDX-1, wherein the culture comprises a histone deacetylase inhibitor.
Dependencies are inferred from the claim text.