Long term expression of lentiviral vectors
OwnerLung-Ji Changinventor
Life of this patent
Estimating the term…
Abstract
Lentiviral vectors that include a transgene and one or more copies of the cHS4 insulator in a forward or reverse orientation, when expressed in cells, exhibit prolonged transgene expression compared to vectors lacking the insulator.
Claims18
A nucleic acid molecule comprising a first nucleotide sequence derived from a lentivirus, a second nucleotide sequence not derived from the lentivirus, and a third nucleotide sequence that comprises an insulator.
A cell into which has been introduced a nucleic acid molecule comprising a first nucleotide sequence derived from a lentivirus, a second nucleotide sequence not derived from the lentivirus, and a third nucleotide sequence that comprises an insulator.
A method for promoting long term expression of a lentiviral vector in a cell, the method comprising the step of introducing into the cell a nucleic acid molecule comprising a first nucleotide sequence derived from a lentivirus, a second nucleotide sequence not derived from the lentivirus, and a third nucleotide sequence that comprises an insulator.
Dependencies are inferred from the claim text.