Antisense modulation of selenophosphate synthetase 2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsAndrew T. Watt, Susan M. Freier
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of selenophosphate synthetase 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding selenophosphate synthetase 2. Methods of using these compounds for modulation of selenophosphate synthetase 2 expression and for treatment of diseases associated with expression of selenophosphate synthetase 2 are provided.
Claims11
An antisense oligonucleotide 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding selenophosphate synthetase 2, wherein said antisense oligonucleotide specifically hybridizes with said nucleic acid molecule encoding selenophosphate synthetase 2 and has a sequence comprising SEQ ID NO:
- 13, 24, 25, 26, 27, 28, 29, 32, 33, 35, 36, 37, 38, 40, 42, 45, 46, 47, 49, 51, 54, 55, 56, 57, 58, 59, 60, 63, 64, 65, 67, 69, 70, 71, 73, 76, 77, 83, 86 or 87.
A compound 8 to 80 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of a hybridization-accessible site on a nucleic acid molecule encoding selenophosphate synthetase 2.
Dependencies are inferred from the claim text.