Antisense modulation of hypothetical protein LOC51249 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorKenneth W. Dobie
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of hypothetical protein LOC51249. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hypothetical protein LOC51249. Methods of using these compounds for modulation of hypothetical protein LOC51249 expression and for treatment of diseases associated with expression of hypothetical protein LOC51249 are provided.
Claims20
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding hypothetical protein LOC51249, wherein said compound specifically hybridizes with said nucleic acid molecule encoding hypothetical protein LOC51249 and inhibits the expression of hypothetical protein LOC51249.
A compound 8 to 80 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of a preferred target region on a nucleic acid molecule encoding hypothetical protein LOC51249.
A method of screening for an antisense compound, the method comprising the steps of:
- a. contacting a preferred target region of a nucleic acid molecule encoding hypothetical protein LOC51249 with one or more candidate antisense compounds, said candidate antisense compounds comprising at least an 8-nucleobase portion which is complementary to said preferred target region, and
- b. selecting for one or more candidate antisense compounds which inhibit the expression of a nucleic acid molecule encoding hypothetical protein LOC51249.
Dependencies are inferred from the claim text.