Novel compounds
AssigneeBeecham Group Limited
InventorsMartin Karl Russel Burnham, Ian David Normansell, John Edward Hodgson
Life of this patent
Estimating the term…
Abstract
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin β-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.
Claims15
DNA (I) or a restriction fragment derived therefrom containing one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin β-lactams, the said DNA having the configuration or restriction sites shown in FIG. 1(a).
S. clavuligerus NCIB 12208.
The use of DNA (I) or any fragment thereof capable of hybridising to the DNA of a β-lactam antibiotic producing micro-organism for the purpose of isolating genes involved in β-lactam antibiotic biosynthesis in that organism.
Dependencies are inferred from the claim text.