Therapeutic polypeptides, nucleic acids encoding same, and methods of use

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

• a) a mature form of the amino acid sequence given SEQ ID NO:
• 2n, wherein n is an integer between 1 and 86;
• b) a variant of a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO:
• 2n, wherein n is an integer between 1 and 86, wherein any amino acid in the mature form of the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed;
• c) the amino acid sequence selected from the group consisting of SEQ ID NO:
• 2n, wherein n is an integer between 1 and 86;
• d) a variant of the amino acid sequence selected from the group consisting of SEQ ID NO:
• 2n, wherein n is an integer between 1 and 86, in which any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed;
• e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:
• 2n, wherein n is an integer between 1 and 86, or any variant of the polypeptide wherein any amino acid of the chosen sequence is changed to a different amino acid, provided that no more than 10% of the amino acid residues in the sequence are so changed;
• and
• f) the complement of any of the nucleic acid molecules.