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US 2004/0002084 A1Published application
Nucleic acids, polypeptides, vectors, and cells derived from activated eosinophil cells
OwnerStanton B. Dotson, Xiao Jun Mainventors
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OwnerStanton B. Dotson, Xiao Jun Mainventors
Estimating the term…
This invention relates to the immune response activity of eosinophils, and especially activated eosinophils, and provides isolated nucleic acids, polypeptides, including fragments, subunits and variants of the nucleic acids and polypeptides, as well as related compositions, probes, vectors, host cells, antibodies, and methods. In one aspect, the invention provides isolated nucleic acids encoding specific eosinophil-derived polypeptides or fragments or variants. Generally, the nucleic acids comprise a sequence encoding at least one domain or region associated with an eosinophil biochemical pathway function or associated with activated eosinophils. And, generally, corresponding domains or regions of polypeptides of the invention have at least a five amino acid fragment encoded by one of SEQ NOS: 1-71. Both the nucleic acids and the polypeptides of the invention can be used as probes, targets, or elements of numerous methods for identifying agents or compositions useful in the treatment of asthma or in methods for diagnosing or identifying eosinophil-related disorders in humans and mammals.
A substantially-purified nucleic acid having a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid having at least one 10 nucleotide region substantially identical to a sequence identified in Table 1.
A computer-readable medium having recorded thereon the sequence information of one or more of SEQ NO:1 through SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 20 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 50 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 100 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A process for diagnosis or prognosis of asthma in a mammal from the expression of mRNA or cDNA that is identical to at least 20 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A method of isolating a nucleic acid that is identical to at least 20 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid as described in Table 7 having a product score of 100.
A substantially-purified nucleic acid as described in Table 8 having a product score between 50 and 99.
A substantially-purified nucleic acid as described in Table 9 having a product score of 0.
A substantially-purified nucleic acid as described in Table 10 having a product score between 1 and 49.
Dependencies are inferred from the claim text.