US 2004/0002068 A1 · Compositions and methods for the detection, diagnosis and therapy of hematological malignancies

Abstract

Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.

Claims26

Dependent claims

An isolated polynucleotide comprising a sequence selected from the group consisting of:

(a) the sequences provided in SEQ ID NOs:10,486-10,536;
SEQ ID NOs:10,537-10,580;
SEQ ID NOs:10,581-10,596;
SEQ ID NO:10,597;
SEQ ID NO:10,845;
SEQ ID NO:10,846;
SEQ ID NO:10,970;
SEQ ID NO:10,971;
SEQ ID NO:10,972;
SEQ ID NO:10,973;
and SEQ ID NO:10,974;
(b) complements of any of the sequences provided in SEQ ID NOs:10,486-10,536;
SEQ ID NOs:10,537-10,580;
SEQ ID NOs:10,581-10,596;
SEQ ID NO:10,597;
SEQ ID NO:10,845;
SEQ ID NO:10,846;
SEQ ID NO:10,970;
SEQ ID NO:10,971;
SEQ ID NO:10,972;
SEQ ID NO:10,973;
and SEQ ID NO:10,974;
(c) sequences having at least 90% identity to any one of the sequences provided in SEQ ID NOs:10,486-10,536;
SEQ ID NOs:10,537-10,580;
SEQ ID NOs:10,581-10,596;
SEQ ID NO:10,597;
SEQ ID NO:10,845;
SEQ ID NO:10,846;
SEQ ID NO:10,970;
SEQ ID NO:10,971;
SEQ ID NO:10,972;
SEQ ID NO:10,973;
and SEQ ID NO:10,974;
and
(d) degenerate variants of any one of the sequences provided in SEQ ID NOs:10,486-10,536;
SEQ ID NOs:10,537-10,580;
SEQ ID NOs:10,581-10,596;
SEQ ID NO:10,597;
SEQ ID NO:10,845;
SEQ ID NO:10,846;
SEQ ID NO:10,970;
SEQ ID NO:10,971;
SEQ ID NO:10,972;
SEQ ID NO:10,973;
and SEQ ID NO:10,974.

42 more elements

Dependencies are inferred from the claim text.

Compositions and methods for the detection, diagnosis and therapy of hematological malignancies

Life of this patent

Compositions and methods for the detection, diagnosis and therapy of hematological malignancies

Life of this patent

Abstract

Claims26