Breast cancer progression signatures
OwnerMark G. Erlander, Xia-Jun Ma +1inventors
InventorsMark G. Erlander, Xia-Jun Ma, Dennis C. Sgroi
Life of this patent
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Abstract
Methods and compositions for the identification of breast cancer progression signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages of breast cancer.
Claims29
An array comprising more than one of the genes in any one of Tables 2-5 hybridized to nucleic acids derived from a cell suspected of being abnormal or malignant.
An array comprising more than one of the genes in Tables 1 or 6 hybridized to nucleic acids derived from a cell suspected of being hyperplastic or cancerous.
An array comprising more than one of the genes in Table 7 hybridized to nucleic acids derived from a DCIS cell.
An array comprising more than one of the genes in Table 8 hybridized to nucleic acids derived from a IDC cell.
The method of claim 15 wherein said assaying comprises preparing RNA from said sample.
A method to determine the breast cancer stage of a ductal lavage or fine needle aspiration sample from a subject comprising assaying said sample for expression of one or more genes correlated with one or more stages of breast cancer.
A method to determine breast cancer stage of a cell containing sample from a subject comprising assaying said sample for expression of one or more genes capable of discriminating between two stages of breast cancer.
A method to determine therapeutic treatment for a patient determined to have atypical cells in a sample therefrom comprising
- assaying said cells for expression of genes correlated with non-cancerous and cancerous breast cancer cells, identifying the stage of breast cancer of said cells, and
- selecting the appropriate treatment for a patient having cells of such a stage.
A method to identify genes the expression of which are correlated with one or more stages of breast cancer comprising
- obtaining multiple homogenous populations of breast cancer cells from each of said one or more stages;
- identifying more than one gene the expression of which is correlated with said one or more stage by detecting genes with similar expression profiles in more than one of said populations.
Dependencies are inferred from the claim text.