SQV nucleic acids and polypeptides
AssigneeMassachusetts Institute of Technology
InventorsH. Robert Horvitz, Ho Yon Hwang
Life of this patent
Estimating the term…
Abstract
The invention generally features sqv nucleic acid and polypeptide molecules associated with connective tissue diseases, progeroid disorders, and aging, and methods for isolating such molecules.
Claims17
A screening method for identifying a compound that modulates the glycosaminoglycan biosynthetic biological activity of a SQV polypeptide, or fragment thereof, said method comprising the steps of:
- (a) providing a SQV polypeptide, or fragment thereof, wherein said polypeptide has a glycosaminoglycan biosynthetic biological activity;
- (b) contacting said polypeptide with a compound;
- and
- (c) detecting the level of biological activity of said polypeptide contacted with said compound with the level of biological activity in polypeptide not contacted with said compound;
- wherein an alteration in said biological activity indicates that said compound modulates the glycosaminoglycan biosynthetic biological activity of a SQV polypeptide.
A method of identifying a compound that modulates a glycosaminoglycan biosynthetic biological activity, said method comprising the steps of:
- (a) providing a cell comprising a sqv nucleic acid molecule;
- (b) contacting said cell with a candidate compound;
- and
- (c) detecting an alteration in a glycosaminoglycan biosynthetic biological activity of said cell, wherein said alteration identifies said compound as modulating a glycosaminoglycan biosynthetic biological activity.
An isolated sqv-5 nucleic acid molecule, or fragment thereof, that encodes a polypeptide sequence having 35% amino acid sequence identity to SEQ ID NO:
- 24, wherein said nucleic acid molecule has a glycosaminoglycan biosynthetic biological activity.
Dependencies are inferred from the claim text.