Lapachone delivery systems, compositions and uses related thereto
AssigneeCase Western Reserve University
InventorsDavid Boothman, Jinming Gao, Norased Nasongkla, John Pink
Life of this patent
Estimating the term…
Abstract
In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and using the same. In another part, the present invention includes inclusion complexes of a lapachone or a prodrug thereof and a cyclodextrin, preferably a β-cyclodextrin, such as hydroxypropyl β-cyclodextrin, e.g., to improve the solubility of the lapachone or prodrug thereof.
Claims28
A drug delivery system, comprising a lapachone or a prodrug thereof incorporated in a biocompatible polymer.
A lapachone or a prodrug thereof complexed with a β-cyclodextrin.
A kit comprising a lapachone or a prodrug thereof, a β-cyclodextrin, and instructions for combining the lapachone and β-cyclodextrin to form a complex and administering the complex to a patient.
Dependencies are inferred from the claim text.