Methods of inhibiting angiogenesis using NADPH oxidase inhibitors
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsWilliam C. Aird, Ruhul Abid
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Abstract
Methods of inhibiting angiogenesis, endothelial cell migration or endothelial cell proliferation, by inhibiting NADPH oxidase inhibitors, production of reactive oxygen species, or by inhibition of mRNA induction of superoxide dismutase (e.g., mitochondrial SOD), are described herein.
Claims87
A method of inhibiting angiogenesis in a tissue, the method comprising contacting the tissue with an inhibitor of NADPH oxidase.
A method of inhibiting angiogenesis in a tissue, the method comprising inhibiting the production of reactive oxygen species (ROS) in the tissue.
A method of inhibiting angiogenesis in a tissue, the method comprising inhibiting induction of mRNA of a superoxide dismutase (SOD) in the tissue.
A method of inhibiting endothelial cell migration in a tissue, the method comprising contacting the tissue with an inhibitor of NADPH oxidase.
A method of inhibiting endothelial cell migration in a tissue, the method comprising inhibiting the production of reactive oxygen species (ROS) in the tissue.
A method of inhibiting endothelial cell migration in a tissue, the method comprising inhibiting induction of mRNA of a superoxide dismutase (SOD) in the tissue.
A method of inhibiting endothelial cell proliferation in a tissue, the method comprising contacting the tissue with an inhibitor of NADPH oxidase.
A method of inhibiting endothelial cell proliferation in a tissue, the method comprising inhibiting the production of reactive oxygen species (ROS) in the tissue.
A method of inhibiting endothelial cell proliferation in a tissue, the method comprising inhibiting induction of mRNA of a superoxide dismutase (SOD) in the tissue.
A composition comprising an inhibitor of NADPH oxidase, the composition having one or more properties selected from the group consisting of:
- the ability to inhibit angiogenesis, the ability to inhibit endothelial cell migration, the ability to inhibit endothelial cell proliferation and the ability to inhibit VEGF-mediated angiogenesis;
- wherein the composition optionally further comprises a pharmaceutically compatible carrier.
A composition comprising an inhibitor of ROS production, the composition having one or more properties selected from the group consisting of:
- the ability to inhibit angiogenesis, the ability to inhibit endothelial cell migration, the ability to inhibit endothelial cell proliferation and the ability to inhibit VEGF-mediated angiogenesis;
- wherein the composition optionally further comprises a pharmaceutically compatible carrier.
A composition comprising an inhibitor of induction of mRNA of a SOD, the composition having one or more properties selected from the group consisting of:
- the ability to inhibit angiogenesis, the ability to inhibit endothelial cell migration, the ability to inhibit endothelial cell proliferation and the ability to inhibit VEGF-mediated angiogenesis;
- wherein the composition optionally further comprises a pharmaceutically compatible carrier.
Dependencies are inferred from the claim text.