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AssigneeSurModics, Inc.
InventorsRalph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
A method for selecting an optimal bioactive agent release rate from a coated composition on a device to be positioned in vivo, the method comprising the steps of:
36 A method according to one of claims 1, 15, 21, or 31 wherein the composition further comprises a solvent in which the polymers form a true solution.
Dependencies are inferred from the claim text.