Particulate materials
AssigneeNektar Therapeutics
InventorsPeter York, Boris Yu Shekunov, Mahboob Ur Rehman, Jane Catherine Feeley
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Abstract
The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.
Claims43
An active substance in particulate form suitable for administration via a dry powder inhaler, said particulates comprising:
- a) a volume mean aerodynamic diameter of less than 7 microns;
- b) a density less than 0.5 g/ml;
- and
- c) a surface-to-volume ratio of at least twice that of spherical particles of the same volume diameter.
An active substance in particulate form which when delivered using a passive dry powder inhaler yields a fine particle fraction in the emitted dose which is at least 20% greater than that of the same active substance produced by micronisation, granulation, or solvent crystallization and having the same or smaller volume mean diameter.
An active substance in particulate form which when dispersed at a shear stress of between 5 and 30 Nm2 gives a volume mean particle diameter at least 10% smaller than that for the same active substance made by micronisation, granulation, or solvent crystallization.
Dependencies are inferred from the claim text.