Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them

A complex and/or complex-forming K′ of the formulae

• 40
• wherein
• n and m in each case are the number 0, 1, 2, 3 or 4, n and m adding up to no more than 4,
• k means the number 1, 2, 3, 4 or 5,
• l means the number 0, 1, 2, 3, 4 or 5,
• q means the number 0, 1 or 2,
• U′ means —CH2C*O—, CH2X′ or V″,
• X′ means in each case independently the residues —COOH, COOY or V′″,
• wherein
• Y is an acid blocking group or a metal ion equivalent of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, and
• V′″ means a substituent to be converted into V′,
• C*O stands for an activated carbonyl group,
• B, D and E, being identical or different, mean in each case the group (CH2)a where a means the number 2, 3, 4 or 5,
• R1′ is V″ r a hydrogen atom, with the proviso that R1′ stands for V″ only if U′ means CH2X′ at the same time, and that U′ means —CH2C*O— or V″ only if R1′ means a hydrogen atom at the same time,
• and where V″ means
• —CH2—CHOH—CH2—NCS;
• —CH2—CHOH—CH2—O—(CH2)2—NCS;
• —CH2—CHOH—CH2—O—(CH2)2—NH—CO—CH2—Br:
• —CH2—CHOH—CH2—O—(CH2)2—O—(CH2)—NCS;
• —NCS;
• —CH2—CHOH—CH2—O—CH2—CHO;
• —CH2—CHOH—CHO;
• 41