Phosphorylated proteins and uses related thereto
AssigneesMDS Proteomics Inc., University of Virginia
InventorsDaniel J. Burke, Mark M. Ross, P. Todd Stukenberg, Forest M. White
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Abstract
Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.
Claims39
A peptide of 4-20 amino acids in length including one or more phosphopeptide sequences shown in Table 1, or corresponding phosphopeptide sequence(s) of a homologous mammalian protein.
An isolated or recombinant polypeptide which includes one or more phosphopeptide sequences shown in Table 1, or corresponding phosphopeptide sequence(s) of a homologous mammalian protein.
A peptidomimetic including a phosphopeptide sequences shown in Table 1, or corresponding phosphopeptide sequence(s) of a homologous mammalian protein, having one or more peptide bond replacements or non-naturally occurring amino acid sidechains, wherein the peptidomimetic.
An isolated antibody, or fragment thereof, specifically immunoreactive with a phosphopeptide sequences shown in Table 1, or corresponding phosphopeptide sequence(s) of a homologous mammalian protein.
Purified preparation of polyclonal antibodies, or fragment thereof, specifically immunoreactive with a phosphopeptide sequences shown in Table 1, or corresponding phosphopeptide sequence(s) of a homologous mammalian protein.
Dependencies are inferred from the claim text.