Methods and compositions for the treatment of disorders of HIV infection
OwnerIrwin H. Gelman, Paul Klotman +1inventors
InventorsIrwin H. Gelman, Paul Klotman, Ming Ming Zhou
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and compositions for use in the intervention of diseases associated with HIV infection. In exemplary embodiments, methods and compositions for the treatment of HIV associated nephropathy (HIVAN) are disclosed.
Claims48
A method of inhibiting kidney cell dedifferentiation, comprising inhibiting the interaction of Nef with a Src family tyrosine kinase SH3 domain of a polypeptide of said cell.
A transgenic non-human animal, wherein a podocyte of said animal comprises an HIV-1 Nef gene under the control of a kidney cell-specific promoter.
A recombinant host cell, wherein said cell is transformed with an expression construct comprising a nucleic acid that encodes HIV-1 Nef under the control of a kidney cell-specific promoter.
A method for screening for agents that modulate nephropathy comprising:
- a) providing a cell expressing HIV-1 Nef;
- b) contacting said cell with a candidate modulator;
- and
- c) monitoring said cell for change in a cellular property associated with nephropathy that occurs in the presence of said modulator.
A peptide composition comprising a sequence selected from the group consisting of the peptide sequences described in Table 1 and Table 1A.
A method of treating a subject, comprising inhibiting the interaction of Nef with a SH3 domain of a Src family tyrosine kinase, wherein said subject has a disease associated with HIV-1 infection.
Dependencies are inferred from the claim text.