US 2003/0229904 A1 · Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer

Abstract

A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.

Claims51

Dependent claims

A composition comprising:

a substance that a) modulates the status of a protein of FIG. 2 (SEQ ID NOS:______), or b) a molecule that is modulated by a protein of FIG. 2, whereby the status of a cell that expresses a protein of FIG. 2 is modulated.

Dependencies are inferred from the claim text.

Facts

Application

10/120,885Filed 9 Apr 2002

Priority

10 Apr 2001

Published

11 Dec 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07K 14/4748
Not used: tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
A61K 40/19
Characterised by the cell type used: dendritic cells
A61K 40/24
Characterised by the effect or the function of the cells: antigen-presenting cells [APC]
A61K 40/42
Vertebrate antigens: cancer antigens

Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer

Life of this patent

Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer

Life of this patent

Abstract

Claims51