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AssigneeMerial Limited
InventorsJeffrey W. Warmke, Youfeng Yang, Doris F. Cully, Michel J. Hamelin
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The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associated R. sanguineus glutamate gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Rhipicephalus sanguineus glutamate gated chloride channels, which will be useful as insecticides.
A purified nucleic acid molecule encoding a R. sanguineus GluCl channel protein, wherein said nucleic acid molecule comprises:
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein, wherein said protein comprises an amino acid sequence as set forth in SEQ ID NO:2:
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein which consists of a nucleotide sequence as set forth in SEQ ID NO:1.
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein, wherein said protein comprises an amino acid sequence as set forth in SEQ ID NO:4.
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein which consists of a nucleotide sequence as set forth in SEQ ID NO:3.
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein, wherein said protein comprises an amino acid sequence as set forth in SEQ ID NO:6.
A purified DNA molecule encoding a R. sanguineus GluCl1 channel protein which consists of a nucleotide sequence as set forth in SEQ ID NO:5.
A purified DNA molecule encoding a R. sanguineus GluCl2 channel protein, wherein said protein comprises an amino acid sequence as set forth in SEQ ID NO:8.
A purified DNA molecule encoding a R. sanguineus GluCl2 channel protein which consists of a nucleotide sequence as set forth in SEQ ID NO:7.
A R. sanguineus GluCl1 channel protein substantially free from other proteins which comprises an amino acid sequence as set forth in SEQ ID NO:2.
A R. sanguineus GluCl1 channel protein substantially free from other proteins which comprises an amino acid sequence as set forth in SEQ ID NO:4.
A R. sanguineus GluCl1 channel protein substantially free from other proteins which comprises an amino acid sequence as set forth in SEQ ID NO:6.
A R. sanguineus GluCl2 channel protein substantially free from other proteins which comprises an amino acid sequence as set forth in SEQ ID NO:8.
A R. sanguineus GluCl1 channel protein which consists of an amino acid sequence selected from the group consisting of amino acid sequences as set forth in SEQ ID NO:2, SEQ ID NO:4, and SEQ ID NO:6.
A R. sanguineus GluCl2 channel protein which consists of an amino acid sequence as set forth in SEQ ID NO:8.
A method of identifying a modulator of a GluCl channel protein, comprising:
A method of identifying a compound that modulates glutamate-gated channel protein activity, which comprises:
Dependencies are inferred from the claim text.