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AssigneeAdherex Technologies, Inc.
InventorsOrest W. Blaschuk, James Matthew Symonds, Barbara J. Gour
Estimating the term…
Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a nonclassical cadherin CAR sequence; (b) a non-peptide mimetic of a nonclassical cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a nonclassical cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a nonclassical cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating nonclassical cadherin-mediated cell adhesion in a variety of contexts are also provided.
A modulating agent that:
A modulating agent that:
A modulating agent that:
A modulating agent that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that specifically binds to a nonclassical cadherin CAR sequence and modulates a nonclassical cadherin-mediated function, wherein the nonclassical cadherin CAR sequence has the formula:
A modulating agent comprising a mimetic of a nonclassical cadherin CAR sequence that comprises at least three consecutive amino acid residues of a nonclassical cadherin CAR sequence having the formula
A modulating agent comprising a mimetic of a nonclassical cadherin CAR sequence that comprises at least five consecutive amino acid residues of a nonclassical cadherin CAR sequence having the formula
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
A modulating agent comprising an antibody or antigen-binding fragment thereof that:
Dependencies are inferred from the claim text.