Back to results
US 2003/0229147 A1Published application
Triarylmethane derivatives and their use as photochemotherapeutic agents
AssigneeWisconsin Alumni Research Foundation
InventorGuilherme L. Indig
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds having one of the following structures: 1 wherein R and R′ are hydrogen or substituted or unsubstituted C1 to C6 linear or branched alkyl, and at least one X is a halogen atom, pharmaceutical compositions containing the compounds as active ingredients, and methods for using the compounds in the photodynamic treatment of cancers.
Claims26
A method of selectively killing cancer cells or selectively inhibiting the growth of cancer cells, comprising:
- (a) contacting a mixture comprising cancerous cells and non-cancerous cells with an effective amount of at least one compound having a structure represented by Formula I or Formula II:
- 8
- or pharmaceutically acceptable salts thereof, wherein each R and R′ is independently selected from the group consisting of hydrogen atoms and substituted or unsubstituted C1-C6 linear or branched alkyl groups, further wherein each X is independently selected from the group consisting of hydrogen and halogen atoms, and still further wherein for compounds having the structure of Formula I, at least one X in the compound is a halogen atom;
- and
- (b) exposing the mixture comprising the cancerous cells and the non-cancerous cells from (a) to light of a suitable wavelength to photoactivate the at least one compound, wherein the cancerous cells are characterized in that the photoactivated compound exhibits selective phototoxicity toward the cancerous cells over the non-cancerous cells.
2 more elements
A compound, the compound comprising a structure represented by Formula I or Formula II:
- 10
- or salts thereof, wherein each R and R′ is independently selected from the group consisting of hydrogen atoms and substituted or unsubstituted C1-C6 linear or branched alkyl groups, further wherein each X is independently selected from the group consisting of hydrogen and halogen atoms, and still further wherein at least one X in the compound is a halogen atom.
A pharmaceutical composition comprising:
- (a) a pharmaceutically effective amount of at least one compound having a structure represented by Formula I or Formula II:
- 12
- or pharmaceutically acceptable salts thereof, wherein each R and R′ is independently selected from the group consisting of hydrogen atoms and substituted or unsubstituted C1-C6 linear or branched alkyl groups, further wherein each X is independently selected from the group consisting of hydrogen and halogen atoms, and still further wherein for compounds having the structure of Formula 1, at least one X in the compound is a halogen atom;
- and
- (b) a pharmaceutically suitable amount of a carrier or diluent.
2 more elements
Dependencies are inferred from the claim text.