Pain treatment methods and compositions

A pharmaceutical composition for treating hyperalgesia, allodynia, hot flash, postmenopausal complaint, amyotrophic lateral sclerosis (ALS), reflex sympathetic dystrophy (RSD), spastic paralysis, restless leg syndrome, acquired nystagmus;

• a psychiatric or neuropathological disorders;
• painful diabetic neuropathy, a symptom due to multiple sclerosis or Parkinson's disease, a neurodegenerative disease;
• a gastric intestinal injury;
• erythromelalgic or post-poliomyelitic pain, trigeminal or post-therapeutic neuralgia;
• or for anticonvulsive or anxiolytic treatment,
• wherein the pharmaceutical composition comprises a pharmaceutically acceptable excipient and an effective amount of a compound of Formula I,
• 40
• in which
• one of R1 and R2 denotes C1-3 alkyl, in each case unsubstituted or mono- or polysubstituted;
• and the other of R1 and R2 denotes branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted C3-10 alkyl;
• or aryl, or heteroaryl, unsubstituted or monosubstituted;
• or unsubstituted or monosubstituted C3-8 cycloalkyl;
• or
• R1 and R2 together denote substituted or unsubstituted (CH2)5, so that a substituted or unsubstituted cyclohexyl is obtained.