Methods of inhibiting osteoclast activity
OwnerShoujun Chen, Joel McCleary +1inventors
InventorsShoujun Chen, Joel McCleary, Lijun Sun
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Abstract
Kavalactones having osteoclast inhibitory activity are described. The kavalactones, and compositions thereof, are useful in mediating osteoclast activity, and as such, are useful in treating or preventing disease or disease symptoms mediated by osteoclast activity.
Claims17
A method of treating or preventing the excessive resorption of bone in a subject comprising the administration of an effective amount of active kavalactone selected from the group consisting of dihydrokawain, dihydromethysticin, kawain, methysticin, yangonin, desmethoxyyangonin and a combination thereof.
A method of treating or preventing disease or disease symptoms in a subject comprising the administration of an effective amount of active kavalactone selected from the group consisting of dihydrokawain, dihydromethysticin, kawain, methysticin, yangonin, desmethoxyyangonin and a combination thereof.
A method of inhibiting osteoclast activity in a subject comprising the administration of an effective amount of active kavalactone selected from the group consisting of dihydrokawain, dihydromethysticin, kawain, methysticin, yangonin, desmethoxyyangonin and a combination thereof.
Dependencies are inferred from the claim text.