Piperidine CCR-3 receptor antagonists

A compound of Formula (I):

• 96
• wherein:
• R1 is (C1-C2)alkylene;
• R2 is optionally substituted phenyl;
• R3 is hydrogen, alkyl, acyl, aryl, or arylalkyl;
• ring A is a cycloalkyl, heterocyclyl, or optionally substituted phenyl;
• L is —C(═O)—, —C(═S)—, —SO2—, —C(═O)N(Ra)—, —C(═S) N(Ra)—, —SO2 N(Ra)—, —C(═O)O—, —C(═S)O—, —S(═O)2O—;
• where Ra is hydrogen, alkyl, acyl, aryl, arylalkyl, alkoxycarbonyl, or benzyloxycarbonyl;
• X is absent, —(CR′R″)O—, —(CR′R″)S—,—(CR′R″)NRb— or alkylene;
• where R′ and R″ are independently hydrogen or alkyl, and Rb is hydrogen or alkyl;
• R4 is aryl or heteroaryl;
• and
• R5 is hydrogen or alkyl;
• provided that when R1 is —CH2—, R2 is phenyl, R3 is hydrogen, R5 is hydrogen, A is phenyl, L is —C(═O)NH— and X is absent, then R4 is not 2,5-difluorophenyl;
• or
• prodrugs, individual isomers, racemic and non-racemic mixtures of isomers, and pharmaceutically acceptable salts thereof.