New linear cyclic ureas

A compound selected from those of formula (I):

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• wherein:
• V represents a single bond or a linear or branched (C1-C6)alkylene chain,
• M represents a single bond or a linear or branched (C1-C6)alkylene chain,
• A and E each represents nitrogen or CH, but at least one of the two groups A or E represents nitrogen,
• W represents a group of formula (i) or (ii), and also may represent a group of formula (iii) but only when V represents a single bond and A represents nitrogen,
• in which groups of formulae (i), (ii) and (iii):
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• X represents carbonyl, sulphonyl or sulphoxide,
• G1 represents a linear (C2-C4)alkylene chain optionally containing a double bond and/or being optionally substituted by a hydroxyl group,
• G2 represents a single bond or methylene,
• G3 represents:
• a linear (C2-C3)alkylene chain when G2 represents a bond,
• or a linear (C1-C2)alkylene chain when G2 represents methylene, the said alkylene chain in each of those cases optionally containing a double bond,
• T represents phenyl fused with the ring to which it is attached or pyridyl fused with the ring to which it is attached,
• R1 represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched,
• R2a and R2b, which are the same or different, each independently of the other represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, mercapto, linear or branched (C1-C6)alkylthio, linear or branched (C1-C6)trihaloalkyl, cyano, nitro, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety may be linear or branched, linear or branched (C1-C6)trihaloalkoxy, aryloxy, aryl-(C1-C6)alkoxy in which the alkoxy moiety is linear or branched, linear or branched (C1-C6)alkylsulphonate, linear or branched (C1-C6)trihaloalkylsulphonate and linear or branched (C1-C6)alkylsulphonyl,
• or R2a+R2b, taken together in adjacent positions, represent a group selected from methylenedioxy, 1,2-ethylenedioxy, 1,3-propylenedioxy, and ethylene optionally substituted by a group selected from cyano, hydroxymethyl, linear or branched (C1-C6)alkoxycarbonyl, aryloxycarbonyl and aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched,
• R3 represents aryl or heteroaryl-A, each of which groups may optionally be substituted by one or more groups, which may be the same or different, selected from among the definitions of R2a,
• Y represents aryloxy, heteroaryloxy or heteroaryl-B, each of which groups may optionally be substituted by one or more groups, which may be the same or different, selected from among the definitions of R2a,
• its isomers, its hydrates, its solvates and addition salts thereof with a pharmaceutically acceptable acid,
• wherein:
• aryl is understood to mean a group selected from phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl, indenyl and benzocyclobutyl,
• heteroaryl-A is understood to mean a monocyclic aromatic or bicyclic, 5- to 12-membered system containing one or two hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur, and wherein, in the case of a bicyclic system, one of the rings has an aromatic character and the other ring may be aromatic or partially hydrogenated,
• heteroaryl-B is understood to mean a monocyclic aromatic or bicyclic aromatic, 5- to 12-membered system containing from 1 to 3 hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur,
• aryloxy is understood to mean aryl as defined hereinbefore attached to oxygen,
• heteroaryloxy is understood to mean heteroaryl-A as defined hereinbefore attached to an oxygen atom,
• with the proviso that:
• when V represents a single bond and W represents a group of formula (i) wherein R3 represents phenyl, then Y cannot represent 3-indolyl,
• when M represents a single bond and W represents a group of formula (i), then if Y represents a bicyclic heteroaryl-B group wherein one of the rings represents a benzene ring the said group Y cannot be joined to M by the said benzene ring,
• and when M represents a single bond, V represents ethylene and W represents a group of formula (i) wherein R3 represents phenyl, then Y cannot represent 1,2-benzisoxazol-3-yl.