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US 2003/0229096 A1Published application
Substituted imidazol-pyridazine derivatives
AssigneeHoffman-La Roche Inc.
InventorsBernd Buettelmann, Marie-Paule Heitz Neidhart, Georg Jaeschke, Emmanuel Pinard
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Abstract
The present invention relates to compounds of formula 1 wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.
Claims19
A compound of formula
- 23
- wherein
- A is an unsubstituted or substituted cyclic group;
- and
- R is hydrogen or lower alkyl;
- or a pharmaceutically acceptable acid addition salt thereof.
3 more elements
Dependencies are inferred from the claim text.