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US 2003/0229073 A1Published application
Tricyclic compounds and method of treating herpes virus
AssigneeWarner-Lambert Company
InventorsRichard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
Life of this patent
Estimating the term…
Abstract
The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y=O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.
Claims14
A compound of Formula I or a pharmaceutically acceptable salt thereof
- 487
- wherein:
- X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond;
- Y=O, (CH2)m, S, SO, SO2, NH, NR8;
- Z=N, NH, O, NHR8, NR8, S, SO, SO2;
- n=an integer of from 0 to 2;
- m=an integer of 1,2, or 3;
- R1, R2, R3, R4, R5 independently are hydrogen, halogen, hydroxyl, amino, mono or dialkylamino, cyano, nitro, alkyl groups (1-6 carbon atoms), alkoxy groups (1-6 carbon atoms), CF3, OCF3, aminoalkyl (1-6 carbon atoms), aminoaryl, Oaryl, or a heterocyclic ring having 5-7 atoms with 1-4 hetero atoms of N, O or S;
- Ar=phenyl,
- substituted phenyl,
- benzoheterocyclic ring,
- substituted benzoheterocyclic ring,
- heterocyclic ring, or
- substituted heterocyclic ring, which have substitutions R6 or R7;
- R6 and R7 are independently hydrogen, alkyl group (1-6 carbon atoms), cycloalkyl 3-12 carbon atoms), halogen, alkoxy, CF3, aminoalkyl (1-6 carbon atoms), aminoaryl, or a heterocyclic ring of from 5-7 atoms with 1-4 heteroatoms of N, O or S;
- R6 and R7 may also form a ring, optionally cycloalkyl or aryl or substituted aryl;
- R8 is hydrogen, alkyl (1-6 carbon atoms), cycloalkyl (3-12 carbon atoms), phenyl or substituted phenyl wherein the substituents are as defined above.
14 more elements
1 (1-Cyclopropyl-ethyl)-(2-methoxy-dibenzofuran-3-yl)-amine
- 2 Cyclopentyl-(9H-fluoren-2-yl)-amine
- 3 (1-Cyclopropyl-ethyl)-(9H-fluoren-2-yl)-amine
- 4 N3-Cyclopentyl-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 5 Isopropyl-(2-methoxy-dibenzofuran-3-yl)-amine
- 6 (2-Methoxy-dibenzofuran-3-yl)-(tetrahydro-thiopyran-4-yl)-amine
- 7 Cycloheptyl-(2-methoxy-dibenzofuran-3-yl)-amine
- 8 (1-Ethyl-propyl)-(2-methoxy-dibenzofuran-3-yl)-amine
- 9 sec-Butyl-(2-methoxy-dibenzofuran-3-yl)-amine
- 10 N2,N2-Dimethyl-N3-piperidin-4-yl-9H-fluorene-2,3-diamine
- 11 N3-(1-Benzyl-butyl)-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 12 (9H-Fluoren-2-yl)-piperidin-4-yl-amine
- 13 (1-Benzyl-butyl)-(9H-fluoren-2-yl)-amine
- 14 sec-Butyl-(9H-fluoren-2-yl)-amine
- 15 (1,1-Dioxo-hexahydro-thiopyran-4-yl)-(2-methoxy-dibenzofuran-3-yl)-amine
- 16 Dibenzofuran-2-yl-(3,3,5,5-tetramethyl-cyclohexyl)-amine
- 17 (Decahydro-naphthalen-1-yl)-dibenzofuran-2-yl-amine
- 18 Adamantan-2-yl-dibenzofuran-2-yl-amine
- 19 Bicyclohexyl-4-yl-dibenzofuran-2-yl-amine
- 20 Bicyclo[2.2.1]hept-2-yl-dibenzofuran-2-yl-amine
- 21 (4-tert-Butyl-cyclohexyl)-dibenzofuran-2-yl-amine
- 22 Bicyclo[3.2.1]oct-2-yl-dibenzofuran-2-yl-amine
- 23 Cyclopentyl-dibenzofuran-2-yl-amine
- 24 Cyclohexyl-(2-methoxy-dibenzofuran-3-yl)-amine
- 25 Cyclohexyl-(9H-fluoren-2-yl)-amine
- 26 Dibenzofuran-2-yl-bis-(3-methylsulfanyl-propyl)-amine
- 27 Dibenzofuran-2-yl-bis-(3-methyl-butyl)-amine
- 28 Dibenzofuran-2-yl-dipropyl-amine
- 29 N3-(1,1-Dioxo-hexahydro-thiopyran-4-yl)-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 30 N3-Isopropyl-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 31 N2,N2-Dimethyl-N3-(tetrahydro-thiopyran-4-yl)-9H-fluorene-2,3-diamine
- 32 N3-Cyclohexyl-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 33 N3-Cycloheptyl-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 34 N3-(1-Ethyl-propyl)-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 35 N3-(1-Cyclopropyl-ethyl)-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 36 N3-sec-Butyl-N2,N2-dimethyl-9H-fluorene-2,3-diamine
- 37 (9H-Fluoren-2-yl)-isopropyl-amine
- 38 (9H-Fluoren-2-yl)-(tetrahydro-thiopyran-4-yl)-amine
- 39 Cycloheptyl-(9H-fluoren-2-yl)-amine
- 40 Dibenzofuran-2-yl-(1,1-dioxo-hexahydro-thiopyran-4-yl)-amine
- 41 Dibenzofuran-2-yl-piperidin-4-yl-amine
- 42 Dibenzofuran-2-yl-isopropyl-amine
- 43 Cyclohexyl-dibenzofuran-2-yl-amine
- 44 (1-Cyclopropyl-ethyl)-dibenzofuran-2-yl-amine
- 45 Dibenzofuran-3-yl-(1,1-dioxo-hexahydro-thiopyran-4-yl)-amine
- 46 Dibenzofuran-3-yl-piperidin-4-yl-amine
- 47 Dibenzofuran-3-yl-isopropyl-amine
- 48 Dibenzofuran-3-yl-(tetrahydro-thiopyran-4-yl)-amine
- 49 Cyclohexyl-dibenzofuran-3-yl-amine
- 50 Cycloheptyl-dibenzofuran-3-yl-amine
- 51 (4-Chloro-benzyl)-dibenzofuran-2-yl-amine
- 52 (4-Chloro-3-nitro-benzyl)-dibenzofuran-2-yl-amine
- 53 Dibenzofuran-2-yl-(3-trifluoromethoxy-benzyl)-amine
- 54 Benzo[1,3]dioxol-5-ylmethyl-dibenzofuran-2-yl-amine
- 55 Dibenzofuran-2-yl-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-amine
- 56 Dibenzofuran-2-yl-(3,5-dimethoxy-benzyl)-amine
- 57 Dibenzofuran-2-yl-(4-trifluoromethyl-benzyl)-amine
- 58 Dibenzofuran-2-yl-(2-methyl-benzyl)-amine
- 59 Dibenzofuran-2-yl-thiophen-3-ylmethyl-amine
- 60 Dibenzofuran-2-yl-(4-nitro-benzyl)-amine
- 61 Dibenzofuran-2-yl-(4-methylsulfanyl-benzyl)-amine
- 62 Dibenzofuran-2-yl-(4-methyl-benzyl)-amine
- 63 Benzyl-dibenzofuran-2-yl-amine
- 64 (3-Benzyloxy-benzyl)-dibenzofuran-2-yl-amine
- 65 (1-Benzyl-butyl)-dibenzofuran-2-yl-amine
- 66 Dibenzofuran-2-yl-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-amine
- 67 3-(Dibenzofuran-2-ylamino)-2-methyl-butan-1-ol
- 68 Dibenzofuran-2-yl-(1-ethyl-butyl)-amine
- 69 Dibenzofuran-2-yl-(1-ethyl-propyl)-amine
- 70 Dibenzofuran-2-yl-(1,3-dimethyl-butyl)-amine
- 71 (1-Cyclohexyl-ethyl)-dibenzofuran-2-yl-amine
- 72 Cyclooctyl-dibenzofuran-2-yl-amine
- 73 Cycloheptyl-dibenzofuran-2-yl-amine
- 74 Dibenzofuran-2-yl-(tetrahydro-thiopyran-4-yl)-amine
- 75 Dibenzofuran-2-yl-(tetrahydro-thiophen-3-yl)-amine
- 76 Dibenzofuran-2-yl-(1,2-dimethyl-propyl)-amine
- 77 Dibenzofuran-2-yl-(1-methyl-butyl)-amine
- 78 sec-Butyl-dibenzofuran-2-yl-amine
- 79 Benzofurp[3,2-b]pyridin-8-yl-(2-fluoro-benzyl)-amine
- 80 Benzofuro[3,3-b]pyridin-8-yl-pyridin-4-ylmethyl-amine
- 81 Benzofuro[3,2-b]pyridin-8-yl-(2-methyl-benzyl)-amine
- 82 N-(2-Fluoro-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 83 N-Methyl-N′-quinolin-4-ylmethyl-dibenzofuran-2,8-diamine
- 84 N-Methyl-N′-naphthanlen-1-ylmethyl-dibenzofuran-2,8-diamine
- 85 N-(4-Methanesulfonyl-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 86 N-Methyl-N′-pyridin-4-ylmethyl-dibenzofuran-2,8-diamine
- 87 N-Methyl-N′-(2-methyl-benzyl)-dibenzofuran-2,8-diamine
- 88 Naphthanlen-1-ylmethyl-(10H-phenothiazin-2-yl)-amine
- 89 (4-Methanesulfonyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 90 (3-Fluoro-2-methyl-benzyl)-(10-oxa-9-thia-1-aza-anthracen-6-yl)-amine
- 91 (2-Fluoro-2-methyl-benzyl)-(10-oxa-9-thia-1-aza-anthracen-6-yl)-amine
- 92 (10-Oxa-9-thia-1-aza-anthracen-6-yl)-qinolin-4-ylmethyl-amine
- 93 Naphthalene-1-ylmethyl-(10-oxa-9-thia-1-aza-anthracen-6-yl)-amine
- 94 (4-Methanesulfonyl-benzyl)-(10-oxa-9-thia-1-aza-anthracen-6-yl)-amine
- 95 (10-Oxa-9-thia-1-aza-anthracen-6-yl)-pyridin-4-ylmethyl-amine
- 96 (2-Methyl-benzyl)-(10-oxa-9-thia-1-aza-anthracen-6-yl)-amine
- 97 Anthracen-2-yl-quinolin-4-ylmethyl-amine
- 98 Anthracen-2-yl-(4-methanesulfonyl-benzyl)-amine
- 99 Anthracen-2-yl-pyridin-4-ylmethyl-amine
- 100 Anthracen-2-yl-(2-methyl-benzyl)-amine
- 101 Dibenzo[b,e][1,4]-dioxin-2-yl-(2-fluoro-benzyl)-amine
- 102 Dibenzo[b,e][1,4]dioxin-2-yl-(2-fluoro-benzyl)-amine
- 103 Dibenzo[b,e][1,4]fioxin-2-yl-quinolin-ylmethyl-amine
- 104 Dibenzo[b,e][1,4]fioxin-2-yl-naphthalen-1-ylmethyl-amine
- 105 Dibenzo[b,e][1,4]fioxin-2-yl-(4-methanesulfonyl-benzyl)-amine
- 106 Dibenzo[b,e][1,4]fioxin-2-yl-pyridin-4-ylmethyl-amine
- 107 8-(3-Fluoro-2-methyl-benzylamino)-dibenzofuran-2-ol
- 108 8-(2-Fluoro-benzylamino)-dibenzofuran2-ol
- 109 8-(4-Methanesulfonyl-benzylamino)-dibenzofuran-2-ol
- 110 8-[(Pyridin-4-ylmethyl)-amino]-dibenzofuran-2-ol
- 111 8-(2-Methyl-benzylamino)-dibenzofuran-2-ol
- 112 (8-Chloro-dibenzofuran-2-yl)-(2-fluoro-benzyl)-amine
- 113 8-Chloro-dibenzofuran-2-yl)-naphthalen-1-ylmethyl-amine
- 114 8-Chloro-dibenzofuran-2-yl)-(4-methanesulfonyl-benzyl)-amine
- 115 (4-Methanesulfonyl-benzyl)-(6,7,8,9-tetrahydro-5H-carbazol-3-yl)-amine
- 116 Pyridin-4-ylmethyl-(6,7,8,9-tetrahydro-5H-carbazol-3-yl)-amine
- 117 Benzofuro[3,2-b]pyridin-8-yl-(3-fluoro-2-methyl-benzyl)-amine
- 118 Dibenzofuran-2-yl-quinolin-4-ylmethyl-amine
- 119 Dibenzofuran-2-yl-quinolin-2-ylmethyl-amine
- 120 (4-Dimethylamino-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 121 Dibenzofuran-2-yl-(4-dimethylamino-benzyl)-amine
- 122 Dibenzofuran-2-yl-(5-nitro-thiophen-2-ylmethyl)-amine
- 123 Dibenzofuran-2-yl-thiazol-2-ylmethyl-amine
- 124 Benzyl-(8-fluoro-dibenzofuran-2-yl)-amine
- 125 N-(-3-Methoxybenzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 126 N-(3,5-Dimethoxy-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 127 N-(4-tert-Butyl-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 128 N-Benzyl-N′-methyl-dibenzofuran-2,8-diamine
- 129 2-[(8-Methylamino-dibenzofuran-2-ylamino)-methyl]-benzonitrile
- 130 (4-Methoxy-benzyl)-phenoxathiin-3-yl-amine
- 131 (8-Chloro-dibenzofuran-2-yl)-(3-methoxy-benzyl)-amine
- 132 (3-Methoxy-benzyl)-phenoxathiin-3-yl-amine
- 133 (3,5-Dimethoxy-benzyl)-phenoxathiin-3-yl-amine
- 134 (3-Fluoro-4-methoxy-benzyl)-phenoxathiin-3-yl-amine
- 135 (4-tert-Butyl-benzyl)-phenoxathiin-3-yl-amine
- 136 Benzyl-phenoxathiin-3-yl-amine
- 137 (2-Ethoxy-benzyl)-phenoxathiin-3-yl-amine
- 138 (8-Chloro-dibenzofuran-2-yl)-(3,5-dimethoxy-benzyl)-amine
- 139 (8-Chloro-dibenzofuran-2-yl)-(3-fluoro-4-methoxy-benzyl)-amine
- 140 Benzyl-(8-chloro-dibenzofuran-2-yl)-amine
- 141 (9H-Fluoren-2-yl)-(4-methoxy-benzyl)-amine
- 142 (8-Chloro-dibenzofuran-2-yl)-thiazol-2-ylmethyl-amine
- 143 (9H-Fluoren-2-yl)-(3-methoxy-benzyl)-amine
- 144 (3,5-Dimethoxy-benzyl)-(9H-fluoren-2-yl)-amine
- 145 (9H-Fluoren-2-yl)-(3-fluoro-4-methoxy-benzyl)-amine
- 146 (4-tert-Butyl-benzyl)-(9H-fluoren-2-yl)-amine
- 147 Benzyl-(9H-fluoren-2-yl)-amine
- 148 (9H-Fluoren-2-yl)-thiazol-2-ylmethyl-amine
- 149 (2-Ethoxy-benzyl)-(9H-fluoren2-yl-amine
- 150 Dibenzofuran-4-yl-(4-methoxy-benzyl)-amine
- 151 2-[(8-Chloro-dibenzofuran-2-ylamino)-methyl]-benzonitrile
- 152 Dibenzofuran-4-yl-(3-methoxy-benzyl)-amine
- 153 Dibenzofuran-4-yl-(3,5-dimethoxy-benzyl)-amine
- 154 Dibenzofuran-4-yl-(3-fluoro-4-methoxy-benzyl)-amine
- 155 (4-tert-Butyl-benzyl)-dibenzofuran-4-yl-amine
- 156 Dibenzofuran-4-yl-(2-ethoxy-benzyl)-amine
- 157 N-(4-Methoxy-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 158 (8-Chloro-dibenzofuran-2-yl)(4-methoxy-benzyl)-amine
- 159 (8-Chloro-dibenzofuran-2-yl)-(2-ethoxy-benzyl)-amine
- 160 Dibenzofuran-4-yl-(2,4-dimethyl-benzyl)-amine
- 161 N-Methyl-N′-thiophen-3-ylmethyl-dibenzofuran-2,8-diamine
- 162 N-Methyl-N′-pyridin-2-ylmethyl-dibenzofuran-2,8-diamine
- 163 (2-Bromo-benzyl)-phenoxathiin-3-yl-amine
- 164 Phenoxathiin-3-yl-quinolin-4-ylmethyl-amine
- 165 Phenoxathiin-3-yl-thiophen-3-ylmethyl-amine
- 166 (3-Methyl-pyridin-2-ylmethyl)-phenoxathiin-3-yl-amine
- 167 Phenoxathiin-3-yl-pyridin-3-ylmethyl-amine
- 168 Phenoxathiin-3-yl-pyridin-2-ylmethyl-amine
- 169 (8-Chloro-dibenzofuran-2-yl)-thiophen-3-ylmethyl-amine
- 170 (2-Bromo-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 171 (8-Chloro-dibenzofuran-2-yl)-(3-methyl-pyridin-2-ylmethyl)-amine
- 172 (9-Ethyl-9H-carbazol-3-yl)-thiophen-3-ylmethyl-amine
- 173 (5-Chloro-thiophen-2-ylmethyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 174 (9-Ethyl-9H-carbazol-3-yl)-pyridin-3-ylmethyl-amine
- 175 (2-Bromo-benzyl)-(9H-fluoren-2-yl)-amine
- 176 (8-Chloro-dibenzofuran-2-yl)-pyridin-4-ylmethyl-amine
- 177 (9H-Fluoren-2-yl)-quinolin-2-ylmethyl-amine
- 178 (9H-Fluoren-2-yl)-thiophen-3-ylmethyl-amine
- 179 (9H-Fluoren-2-yl)-(3-methyl-pyridin-2-ylmethyl)-amine
- 180 (9H-Fluoren-2-yl)-pyridin-4-ylmethyl-amine
- 181 (9H-Fluoren-2-yl)-pyridin-3-ylmethyl-amine
- 182 (9H-Fluoren-2-yl)-pyridin-2-ylmethyl-amine
- 183 (8-Chloro-dibenzofuran-2-yl)-pyridin-3-ylmethyl-amine
- 184 Dibenzofuran-4-yl-quinolin-4-ylmethyl-amine
- 185 Dibenzofuran-4-yl-quinolin-2-ylmethyl-amine
- 186 Dibenzofuran-4-yl-thiophen-3-ylmethyl-amine
- 187 Dibenzofuran-4-yl-(3-methyl-pyridin-2-ylmethyl)-amine
- 188 Dibenzofuran-4-yl-pyridin-4-ylmethyl-amine
- 189 Dibenzofuran-4-yl-pyridin-3-ylmethyl-amine
- 190 Dibenzofuran-4-yl-pyridin-2-ylmethyl-amine
- 191 (2-Bromo-benzyl)-(8-chloro-dibenzofuran-2-yl)-amine
- 192 (8-Chloro-dibenzofuran-2-yl)-pyridin-2-ylmethyl-amine
- 193 N-Methyl-N′-(2,3,6-trifluoro-benzyl)-dibenzofuran-2,8-diamine
- 194 N-Methyl-N′-(2,3,4-trifluoro-benzyl)-dibenzofuran-2,8-diamine
- 195 N-(2,6-Difluoro-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 196 N-(2,5-Difluoro-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 197 N-(2,4-Difluoro-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 198 N-(2,3-Difluoro-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 199 N-(2,5-Dimethyl-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 200 N-(2,4-Dimethyl-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 201 N-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-N′-methyl-dibenzofuran-2,8-diamine
- 202 (3-Fluoro-2-methyl-benzyl)-phenoxathiin-3-yl-amine
- 203 (8-Chloro-dibenzofuran-2-yl)-(2,3,6-trifluoro-benzyl)-amine
- 204 Phenoxathiin-3-yl-(2,3,6-trifluoro-benzyl)-amine
- 205 Phenoxathiin-3-yl-(2,3,4-trifluoro-benzyl)-amine
- 206 (2,6-Difluoro-benzyl)-phenoxathiin-3-yl-amine
- 207 (2,5-Difluoro-benzyl)-phenoxathiin-3-yl-amine
- 208 (2,4-Difluoro-benzyl)-phenoxathiin-3-yl-amine
- 209 (2,3-Difluoro-benzyl)-phenoxathiin-3-yl-amine
- 210 (2,4-Dimethyl-benzyl)-phenoxathiin-3-yl-amine
- 211 (2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-phenoxathiin-3-yl-amine
- 212 Benzo[b]thiophen-5-yl-(3-fluoro-2-methyl-benzyl)-amine
- 213 (8-Chloro-dibenzofuran-2-yl)-(2,3,4-trifluoro-benzyl)-amine
- 214 (8-Chloro-dibenzofuran-2-yl)-(2,6-difluoro-benzyl)-amine
- 215 (8-Chloro-dibenzofuran-2-yl)-(2,5-difluoro-benzyl)-amine
- 216 (8-Chloro-dibenzofuran-2-yl)-(2,4-difluoro-benzyl)-amine
- 217 (9-Ethyl-9H-carbazol-3-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 218 (8-Chloro-dibenzofuran-2-yl)-(2,3-difluoro-benzyl)-amine
- 219 (9-Ethyl-9H-carbazol-3-yl)-(2,3,6-trifluoro-benzyl)-amine
- 220 (9-Ethyl-9H-carbazol-3-yl)-(2,3,4-trifluoro-benzyl)-amine
- 221 (2,6-Difluoro-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 222 (2,5-Difluoro-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 223 (2,4-Difluoro-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 224 (2,3-Difluoro-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 225 (2,5-Dimethyl-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 226 (2,4-Dimethyl-benzyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 227 (2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-(9-ethyl-9H-carbazol-3-yl)-amine
- 228 (9H-Fluoren-2-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 229 (8-Chloro-dibenzofuran-2-yl)-(2,5-dimethyl-benzyl)-amine
- 230 (9H-Fluoren-2-yl)-(2,3,6-trifluoro-benzyl)-amine
- 231 (9H-Fluoren-2-yl)-(2,3,4-trifluoro-benzyl)-amine
- 232 (2,5-Difluoro-benzyl)-(9H-fluoren-2-yl)-amine
- 233 (2,4-Difluoro-benzyl)-(9H-fluoren-2-yl)-amine
- 234 (2,3-Difluoro-benzyl)-(9H-fluoren-2-yl)-amine
- 235 (2,5-Dimethyl-benzyl)-(9H-fluoren-2-yl)-amine
- 236 (2,4-Dimethyl-benzyl)-(9H-fluoren-2-yl)-amine
- 237 (2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-(9H-fluoren-2-yl)-amine
- 238 (8-Chloro-dibenzofuran-2-yl)-(2,4-dimethyl-benzyl)-amine
- 239 Dibenzofuran-4-yl-(2,5-dimethyl-benzyl)-amine
- 240 Dibenzofuran-4-yl-(3-fluoro-2-methyl-benzyl)-amine
- 241 N-(3-Fluoro-2-methyl-benzyl)-N′-methyl-dibenzofuran-2,8-diamine
- 242 (8-Chloro-dibenzofuran-2-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 243 (8-Chloro-dibenzofuran-2-yl)-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-amine
- 244 (2,5-Dimethoxy-benzyl)-phenoxathiin-3-yl-amine
- 245 (2,3-Dimethoxy-benzyl)-phenoxathiin-3-yl-amine
- 246 (2-Chloro-benzyl)-phenoxathiin-3-yl-amine
- 247 (2-Methoxy-benzyl)-phenoxathiin-3-yl-amine
- 248 (2-Methyl-benzyl)-phenoxathiin-3-yl-amine
- 249 Anthracen-2-yl-(2-chloro-benzyl)-amine
- 250 Anthracen-2-yl-(2-fluoro-benzyl)-amine
- 251 Dibenzo[1,4]dioxin-2-yl-(2,3-dimethoxy-benzyl)-amine
- 252 (2-Chloro-benzyl)-dibenzo[1,4]dioxin-2-yl-amine
- 253 2-(Dibenzo[1,4]dioxin-2-ylaminomethyl)-phenol
- 254 Dibenzo[1,4]dioxin-2-yl-(2-methoxy-benzyl)-amine
- 255 2-[(9-Ethyl-9H-carbazol-3-ylamino)-methyl]-phenol
- 256 (9-Ethyl-9H-carbazol-3-yl)-(2-fluoro-benzyl)-amine
- 257 (9-Ethyl-9H-carbazol-3-yl)-(2-methyl-benzyl)-amine
- 258 (2-Chloro-benzyl)-(9H-fluoren-2-yl)-amine
- 259 2-[(9H-Fluoren-2-ylamino)-methyl]-phenol
- 260 (9H-Fluoren-2-yl)-(2-methoxy-benzyl)-amine
- 261 (9H-Fluoren-2-yl)-(2-trifluoromethyl-benzyl)-amine
- 262 (9H-Fluoren-2-yl)-(2-fluoro-benzyl)-amine
- 263 Dibenzofuran-4-yl-(2,5-dimethoxy-benzyl)-amine
- 264 Dibenzofuran-4-yl-(2,3-dimethoxy-benzyl)-amine
- 265 2-(Dibenzofuran-4-ylaminomethyl)-phenol
- 266 Dibenzofuran-4-yl-(2-methoxy-benzyl)-amine
- 267 (2,5-Dimethoxy-benzyl)-(3-methoxy-dibenzofuran-2-yl)-amine
- 268 (2,3-Dimethoxy-benzyl)-(3-methoxy-dibenzofuran-2-yl)-amine
- 269 (2-Methoxy-benzyl)-(3-methoxy-dibenzofuran-2-yl)-amine
- 270 Dibenzofuran-2-yl-(2,5-dimethoxy-benzyl)-amine
- 271 Dibenzofuran-2-yl-(4-methoxy-benzyl)-amine
- 272 (2-Bromo-benzyl)-dibenzofuran-2-yl-amine
- 273 (8-Fluoro-dibenzofuran-2-yl)-(3H-imidazol-4-ylmethyl)-amine
- 274 2-[(8-Fluoro-dibenzofuran-2-ylamino)-methyl]-benzonitrile
- 275 (2-Ethoxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 276 (8-Fluoro-dibenzofuran-2-yl)-(4-methylsulfanyl-benzyl)-amine
- 277 (2-Bromo-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 278 (8-Fluoro-dibenzofuran-2-yl)-quinolin-4-ylmethyl-amine
- 279 (8-Fluoro-dibenzofuran-2-yl)-quinolin-2-ylmethyl-amine
- 280 Dibenzofuran-2-yl-naphthalen-1-ylmethyl-amine
- 281 (8-Fluoro-dibenzofuran-2-yl)-naphthalen-2-ylmethyl-amine
- 282 (8-Fluoro-dibenzofuran-2-yl)-naphthalen-1-ylmethyl-amine
- 283 Dibenzofuran-2-yl-(2-nitro-benzyl)-amine
- 284 Dibenzofuran-2-yl-(3H-imidazol-4-ylmethyl)-amine
- 285 2-(Dibenzofuran-2-ylaminomethyl)-benzonitrile
- 286 Dibenzofuran-2-yl-(2-ethoxy-benzyl)-amine
- 287 Dibenzofuran-2-yl-(3-trifluoromethyl-benzyl)-amine
- 288 (4-tert-Butyl-benzyl)-dibenzofuran-2-yl-amine
- 289 Dibenzofuran-2-yl-(3-fluoro-benzyl)-amine
- 290 (2,5-Dimethoxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 291 (2,3-Dimethoxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 292 (4-Benzyloxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 293 (3-Benzyloxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 294 (4-Chloro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 295 (3-Chloro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 296 (2-Chloro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 297 4-[(8-Fluoro-dibenzofuran-2-ylamino)-methyl]-phenol
- 298 3-[(8-Fluoro-dibenzofuran-2-ylamino)-methyl]-phenol
- 299 Dibenzofuran-2-yl-(2-fluoro-benzyl)-amine
- 300 (8-Fluoro-dibenzofuran-2-yl)-(4-methoxy-benzyl)-amine
- 301 (8-Fluoro-dibenzofuran-2-yl)-(3-methoxy-benzyl)-amine
- 302 (8-Fluoro-dibenzofuran-2-yl)-(2-methoxy-benzyl)-amine
- 303 (8-Fluoro-dibenzofuran-2-yl)-(4-trifluoromethyl-benzyl)-amine
- 304 (8-Fluoro-dibenzofuran-2-yl)-(3-trifluoromethyl-benzyl)-amine
- 305 (4-tert-Butyl-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 306 (4-Fluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 307 (3-Fluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 308 (2-Fluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 309 (8-Fluoro-dibenzofuran-2-yl)-(4-methyl-benzyl)-amine
- 310 (8-Fluoro-dibenzofuran-2-yl)-(3-methyl-benzyl)-amine
- 311 Dibenzofuran-2-yl-(2,6-dimethoxy-benzyl)-amine
- 312 Dibenzofuran-2-yl-(2,4-dimethoxy-benzyl)-amine
- 313 Dibenzofuran-2-yl-(2,3-dimethoxy-benzyl)-amine
- 314 (4Benzyloxy-benzyl)-dibenzofuran-2-yl-amine
- 315 Dibenzofuran-2-yl-(3-methyl-benzyl)-amine
- 316 (3-Chloro-benzyl)-dibenzofuran-2-yl-amine
- 317 3-(Dibenzofuran-2-ylaminomethyl)-phenol
- 318 (2-Chloro-benzyl)-dibenzofuran-2-yl-amine
- 319 Dibenzofuran-2-yl-(3-methoxy-benzyl)-amine
- 320 Dibenzofuran-2-yl-(2-methoxy-benzyl)-amine
- 321 (9H-Fluoren-2-yl)-(2-methyl-benzyl)-amine
- 322 Dibenzofuran-4-yl-(2-methyl-benzyl)-amine
- 323 (8-Chloro-dibenzofuran-2-yl)-(2-methyl-benzyl)-amine
- 324 (2-Methyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 325 Dibenzo[b,e][1,4]dioxin-2-yl-(2-methyl-benzyl)-amine
- 326 Dibenzofuran-2-yl-(2,6-difluoro-benzyl)-amine
- 327 Dibenzofuran-2-yl-(2,5-difluoro-benzyl)-amine
- 328 Dibenzofuran-2-yl-(2,4-difluoro-benzyl)-amine
- 329 Dibenzofuran-2-yl-(2,3-difluoro-benzyl)-amine
- 330 (8-Fluoro-dibenzofuran-2-yl)-thiophen-2-ylmethyl-amine
- 331 Dibenzofuran-2-yl-(2,5-dimethyl-benzyl)-amine
- 332 (8-Fluoro-dibenzofuran-2-yl)-thiophen-3-ylmethyl-amine
- 333 (8-Fluoro-dibenzofuran-2-yl)-furan-2-ylmethyl-amine
- 334 (8-Fluoro-dibenzofuran-2-yl)-furan-3-ylmethyl-amine
- 335 (8-Fluoro-dibenzofuran-2-yl)-(6-methyl-pyridin-2-ylmethyl)-amine
- 336 (8-Fluoro-dibenzofuran-2-yl)-(4-methanesulfonyl-benzyl)-amine
- 337 (8-Fluoro-dibenzofuran-2-yl)-pyridin-4-ylmethyl-amine
- 338 (8-Fluoro-dibenzofuran-2-yl)-pyridin-3-ylmethyl-amine
- 339 (8-Fluoro-dibenzofuran-2-yl)-pyridin-2-ylmethyl-amine
- 340 (8-Fluoro-dibenzofuran-2-yl)-(3-fluoro-4-methoxy-benzyl)-amine
- 341 Dibenzofuran-2-yl-(2,4-dimethyl-benzyl)-amine
- 342 (8-Fluoro-dibenzofuran-2-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 343 (8-Fluoro-dibenzofuran-2-yl)-(2,3,6-trifluoro-benzyl)-amine
- 344 (8-Fluoro-dibenzofuran-2-yl)-(2,3,4-trifluoro-benzyl)-amine
- 345 (3,5-Difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 346 (3,4-Difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 347 (3,5-difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 348 (2,6-Difluoro-benzyl (2,5-Difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 349 (2,4-Difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 350 (2,3-Difluoro-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 351 (2,5-Dimethyl-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 352 (2,4-Dimethyl-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 353 (2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 354 (3,5-Dimethoxy-benzyl)-(8-fluoro-dibenzofuran-2-yl)-amine
- 355 Dibenzofuran-2-yl-furan-2-ylmethyl-amine
- 356 Dibenzofuran-2-yl-furan-3-ylmethyl-amine
- 357 Dibenzofuran-2-yl-(6-methyl-pyridin-2-ylmethyl)-amine
- 358 Dibenzofuran-2-yl-(4-methanesulfonyl-benzyl)-amine
- 359 Dibenzofuran-2-yl-pyridin-4-ylmethyl-amine
- 360 Dibenzofuran-2-yl-pyridin-3-ylmethyl-amine
- 361 Dibenzofuran-2-yl-pyridin-2-ylmethyl-amine
- 362 Dibenzofuran-2-yl-(3-fluoro-4-methoxy-benzyl)-amine
- 363 Dibenzofuran-2-yl-(3-fluoro-2-methyl-benzyl)-amine
- 364 Dibenzofuran-2-yl-(2,3,6-trifluoro-benzyl)-amine
- 365 Dibenzofuran-2-yl-(2,3,4-trifluoro-benzyl)-amine
- 366 Dibenzofuran-2-yl-(3,5-difluoro-benzyl)-amine
- 367 Dibenzofuran-2-yl-(3,4-difluoro-benzyl)-amine
- 368 Dibenzofuran-2-yl-(3,4-dimethoxy-benzyl)-amine
- 369 Dibenzofuran-2-yl-methyl-(2-methyl-benzyl)-amine
- 370 Dibenzothiohen-2-yl-(2,4-dimethyl-benzyl)-amine
- 371 (4-tert-Butyl-benzyl)-dibenzothiohen-2-yl-amine
- 372 (2-Chloro-benzyl)-dibenzothiohen-2-yl-amine
- 373 Dibenzothiohen-2-yl-(2,6-difluoro-benzyl)-amine
- 374 Dibenzothiohen-2-yl-(2,3,6-trifluoro-benzyl)-amine
- 375 Dibenzothiohen-2-yl-(2-fluoro-benzyl)-amine
- 376 Benzyl-dibenzothiohen-2-yl-amine
- 377 Dibenzothiohen-2-yl-(4-methoxy-benzyl)-amine
- 378 Dibenzothiohen-2-yl-(2,3-dimethoxy-benzyl)-amine
- 379 Dibenzothiohen-2-yl-(2,5-difluoro-benzyl)-amine
- 380 Dibenzothiohen-2-yl-(3-methoxy-benzyl)-amine
- 381 Dibenzothiohen-2-yl-(2,3,4-trifuoro-benzyl)-amine
- 382 (-2-Bromo-benzyl)-dibenzothiohen-2-yl-amine
- 383 Dibenzothiohen-2-yl-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-amine
- 384 Dibenzothiohen-2-yl-(3-fluoro-4-methoxy-benzyl)-amine
- 385 Dibenzothiohen-2-yl-(2,5-dimethyl-benzyl)-amine
- 386 Dibenzothiohen-2-yl-thiophen-3-ylmethyl-amine
- 387 Dibenzothiohen-2-yl-naphthalene-1-ylmethyl-amine
- 388 Dibenzothiohen-2-yl-(2-trifluoromethyl-benzyl)-amine
- 389 Dibenzothiohen-2-yl-naphthalen-2-ylmethyl-amine
- 390 Dibenzothiohen-2-yl-(2-ethoxy-benzyl)-amine
- 391 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 392 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2-methyl-benzyl)-amine
- 393 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2,4-dimethyl-benzyl)-amine
- 394 (4-tert-Butyl-benzyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 395 (2-Chloro-benzyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 396 (2,6-Difluoro-benzyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 397 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2,3,6-trifluoro-benzyl)-amine
- 398 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2-fluoro-benzyl)-amine
- 399 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(3,5-dimethoxy-benzyl)-amine
- 400 Benzyl-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 401 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(4-methoxy-benzyl)-amine
- 402 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2,3-dimethoxy-benzyl)-amine
- 403 (2,5-difluoro-benzyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 404 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(3-methoxy-benzyl)-amine
- 405 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2,3,4-trifluoro-benzyl)-amine
- 406 (2-Bromo-benzyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 407 (2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)-(10,11-dihydro-5H-dibenz[b,f]azepin-2-yl)-amine
- 408 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(3-fluoro-4-methoxy-benzyl)-amine
- 409 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2,5-dimethyl-benzyl)-amine
- 410 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-thiophen-3-ylmethyl-amine
- 411 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-naphthalen-1-ylmethyl-amine
- 412 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2-trifluoromethyl-benzyl)-amine
- 413 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-naphthalen-2-ylmethyl-amine
- 414 (10,11-Dihydro-5H-dibenz[b,f]azepin-2-yl)-(2-ethoxy-benzyl)-amine
- 415 (3-Fluoro-2-methyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 416 (2,4-Dimethyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 417 (4-tert-Butyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 418 (2-Chloro-benzyl)-(10H-phenothiazin-2-yl)-amine
- 419 (2,6-Difluoro-benzyl)-(10H-phenothiazin-2-yl)-amine
- 420 (10H-Phenothiazin-2-yl)-(2,3,6-trifluorobenzyl)-amine
- 421 (2-Fluoro-benzyl)-(10H-phenothiazin-2-yl)-amine
- 422 (3,5-Dimethoxy-benzyl)-(10H-phenothiazin-2-yl)-amine
- 423 Benzyl-(10H-phenothiazin-2-yl)-amine
- 424 (4-Methoxy-benzyl)-(10H-phenothiazin-2-yl)-amine
- 425 (2,5-Difluoro-benzyl)-(10H-phenothiazin-2-yl)-amine
- 426 (10H-Phenothiazin-2-yl)-(2,3,4-trifluoro-benzyl)-amine
- 427 (2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)-(10H-phenothiazin-2-yl)-amine
- 428 (3-Fluoro-4-methoxy-benzyl)-(10H-phenothiazin-2-yl)-amine
- 429 (2,5-Dimethyl-benzyl)-(10H-phenothiazin-2-yl)-amine
- 430 (10H-Phenothiazin-2-yl)-thiophen-3-ylmethyl-amine
- 431 (10H-Phenothiazin-2-yl)-(2-trifluoromethyl-benzyl)-amine
- 432 (9H-Carbazol-3-yl)-(3-fluoro-2-methyl-benzyl)-amine
- 433 (9H-Carbazol-3-yl)-(2-methyl-benzyl)-amine
- 434 (9H-Carbazol-3-yl)-(2,4-dimethyl-benzyl)-amine
- 435 (4-tert-Butyl-benzyl)-(9H-carbazol-3-yl)-amine
- 436 (9H-Carbazol-3-yl)-(2-chloro-benzyl)-amine
- 437 (9H-Carbazol-3-yl)-(2,6-difluoro-benzyl)-amine
- 438 (9H-Carbazol-3-yl)-(2,3,6-trifluoro-benzyl)-amine
- 439 (9H-Carbazol-3-yl)-(3,5-dimethoxy-benzyl)-amine
- 440 (9H-Carbazol-3-yl)-(2,3-dimethoxy-benzyl)-amine
- 441 (9H-Carbazol-3-yl)-(2,5-difluoro-benzyl)-amine
- 442 (9H-Carbazol-3-yl)-(2,3,4-trifluoro-benzyl)-amine
- 443 (9H-Carbazol-3-yl)-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-amine
- 444 (9H-Carbazol-3-yl)-(2,5-dimethyl-benzyl)-amine
- 445 (9H-Carbazol-3-yl)-naphthalen-1-ylmethyl-amine
- 446 (9H-Carbazol-3-yl)-naphthalen-2-ylmethyl-amine
- 447 Dibenzofuran-2-yl-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-amine
- 448 Dibenzofuran-2-yl-bis-thiophen-3-ylmethyl-amine
- 449 Dibenzofuran-2-yl-(4-phenoxy-benzyl)-amine
- 450 2-Dibenzofuran-2-yl-2,3-dihydro-1H-isoindole
- 451 2-Dibenzofuran-2-yl-1H-isoindole-1,3-dione
- 452 Dibenzofuran-2-yl-(4-trifluoromethoxy-benzyl)-amine
- 453 Dibenzofuran-2-yl-(2-methoxy-benzyl)-amine
- 454 Dibenzofuran-2-yl-(3-phenoxy-benzyl)-amine
- 455 Dibenzofuran-2-yl-methyl(2-methyl-benzyl)-amine
- 456 Dibenzofuran-2-yl-(1-phenyl-butyl)-amine
- 457 Dibenzofuran-2-yl-phenethyl-amine
- 458 Dibenzofuran-2-yl-(1-phenyl-ethyl)-amine
454 more elements
Dependencies are inferred from the claim text.