Steroidal quinols and their use for antioxidant therapy
AssigneesUniversity of Florida Research Foundation, Inc., University of North Texas Health Science Center
InventorsLaszlo Prokai, Katalin Prokai, James Simpkins
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel estrogen-related steroidal quinols and their use as prodrugs for phenolic estrogens and estrogen analogs. The quinols of the present invention provide improved physicochemical properties, increased bioavailability, and improved distribution into tissues and penetration across the blood-brain barrier when compared to phenolic estrogens and estrogen analogs.
Claims30
A method of providing biologically active estrogen compounds to a mammal, wherein said method comprises administering to the mammal an effective amount of a quinol that is converted to a biologically active estrogen compound via enzyme-catalyzed reduction.
A quinol that is converted to a biologically active estrogen compound via enzyme catalyzed reduction.
A pharmaceutical composition comprising a quinol that is converted to a biologically active estrogen compound via enzyme catalyzed reduction, wherein said composition further comprises a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.