Aqueous ifosfamide composition
AssigneeGensia Sicor Pharmaceuticals, Inc.
InventorsDorla Mirejovsky, Michael Burkhart
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Abstract
This invention is directed towards a ready-to-use aqueous composition of ifosfamide. In one embodiment, the invention is directed to an aqueous ifosfamide composition which comprises ifosfamide, a pharmaceutically acceptable buffer, and water. The concentration of ifosfamide in the composition may be between about 40 mM and about 400 mM. The concentration of buffer in the composition may be between about 10 mM and about 260 mM. The molar ratio of ifosfamide to buffer may be between about 0.5:1 to about 20:1. The pH of the composition may be between about 4 and about 8.
Claims20
An aqueous pharmaceutical composition comprising:
- (a) between 40 mM and 400 mM ifosfamide;
- (b) between 10 mM and 260 mM of a buffer;
- and
- (c) water;
- wherein the molar ratio of ifosfamide to buffer is in the range of about 0.5:1 to about 20:1.
An aqueous pharmaceutical composition comprising:
- (a) between 170 mM and 210 mM ifosfamide;
- (b) between 10 mM and 260 mM of a phosphate buffer;
- and
- (c) water;
- wherein the molar ratio of ifosfamide to buffer is in the range of about 0.5:1 to about 20:1.
Dependencies are inferred from the claim text.