Use of transcription factors for treating inflammation and other diseases
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsPeter Oettgen, Towia Libermann, Mary Goldring
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of treating inflammation in a mammal comprising altering the activity of a transcription factor involved in the inflammatory response. The invention also relates to the use of transcription factors to screen compounds that are capable of reducing inflammation. The invention also relates to the use of transcription factors in methods of diagnosing the presence of an inflammatory disease in a tissue of a mammal and methods of monitoring the treatment of an inflammatory disease in a tissue of a mammal.
Claims71
A method of treating inflammation in a mammal comprising altering the activity of a transcription factor, wherein the transcription factor is involved in mediating the inflammation.
A method of screening compounds that are capable of reducing inflammation comprising:
- (a) providing cells which do not normally express a measurable transcription factor but do express the transcription factor in the presence of a pro-inflammatory agent;
- (b) providing to a portion of the cells a compound to be screened;
- (c) providing a portion of the cells as a control without the compound;
- (d) providing the pro-inflammatory agent to the cells;
- (e) measuring the expression of the transcription factor in the cells, and
- (f) comparing the amount of expression of the transcription factor in the cells containing the compound with the control portion of cells.
A method of monitoring the treatment of an inflammatory disease in a mammal comprising:
- removing a sample from the mammal subsequent to said treatment and measuring the presence or amount of a transcription factor wherein the transcription factor is not present in detectable amounts in the mammal in the absence of the inflammatory disease.
A method of diagnosing the presence of an inflammatory disease in a mammal comprising:
- (a) removing a sample from the mammal and
- (b) measuring the presence of a transcription factor wherein the transcription factor is not present in detectable amounts in the sample in the absence of the inflammatory disease.
A method of altering the expression of an inflammatory response gene comprising modulating the expression of a transcription factor wherein the transcription factor is involved in expression of the gene.
A pharmaceutical composition for the treatment of inflammation comprising a compound that reduces the expression of a transcription factor and a pharmaceutically acceptable carrier.
A method of treating a disease comprising increasing the activity of a transcription factor, wherein the transcription factor is either not expressed in diseased tissue or expressed in low amounts.
A method of treating or preventing inflammation after cartilage implantation in a mammal comprising altering the activity of a transcription factor expressed in said mammal in response to a pro-inflammatory agent, wherein the activity of the transcription factor or the expression of the transcription factor is affected by the pro-inflammatory agent.
Dependencies are inferred from the claim text.