Novel orphan cytokine receptor polypeptides
OwnerPiotr J. Masiakowskiinventor
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Abstract
The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated OCR1. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the MAMMALIAN OCR1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between MAMMALIAN OCR1 and agents that initiate signal transduction through binding to MAMMALIAN OCR1. In a specific embodiment, the MAMMALIAN OCR1 may HUMAN OCR1 or MOUSE OCR1.
Claims18
An isolated nucleic acid molecule encoding HUMAN OCR1.
An isolated nucleic acid molecule encoding a MAMMALIAN OCR1.
Isolated MAMMALIAN OCR1 polypeptide.
A polypeptide comprising the extracellular portion of the MAMMALIAN OCR1 polypeptide fused to an immunoglobulin constant region.
A polypeptide comprising the extracellular portion of the MAMMALIAN OCR1 polypeptide fused to an immunoglobulin Fc region.
Dependencies are inferred from the claim text.