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US 2003/0228644 A1Published application
Pro drugs for selective drug delivery
OwnerRandell L. Millsinventor
Life of this patent
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Abstract
Prodrug compounds capable of permeating a desired biological compartment and releasing a biologically active molecule in active form to effect a therapeutic functional change in the compartment to which it is introduced.
Claims56
A chemical compound having the formula A−B, where
- A is a moiety capable of receiving energy;
- and
- B is a biologically active agent covalently bonded to B, wherein the bond between A and B is capable of heterolytic cleavage upon reception of energy by A.
A method for selectively delivering a biologically active agent to a biological compartment, which comprises:
- introducing a chemical compound having the formula A−B, where A is a carrier moiety and B is a biologically active agent, into said biological compartment;
- and
- exposing said chemical compound to an energy sufficient to cause heterolytic cleavage of said bond between A and B, thereby releasing B from A.
Dependencies are inferred from the claim text.