Dry granulated formulations of azithromycin

An azithromycin tablet comprising

• (a) from about 40 wt % to about 90 wt % azithromycin;
• (b) from about 0 wt % to about 60 wt % binder;
• (c) from 0 wt % to about 60 wt % filler;
• (d) from 0 wt % to about 15 wt % disintegrant;
• and
• (e) from about 0.25 wt % to about 10 wt % lubricant.

A pharmaceutical formulation, comprising:

• a) a capsule;
• b) dry granulated particles of a form of azithromycin selected from the group consisting of azithromycin forms D, E, F, G, H, J, M, N, O, P, Q, R and mixtures of non-dihydrate forms;
• and
• c) at least one pharmaceutically acceptable excipient

A method of preparing an azithromycin pharmaceutical formulation, in a tablet, sachet or powder for suspension dosage form, comprising:

• a) forming a blend of non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient;
• b) compressing the blend to produce a compressed material;
• c) milling the compressed material to produce granules;
• d) processing the granules into a tablet, a a sachet or a powder for suspension.

A method of preparing an azithromycin pharmaceutical formulation, in a capsule dosage form, comprising:

• a) forming a blend of a non-dihydrate azithromycin, wherein said non-dihydrate azithromycin form is selected from azithromycin forms D, E, F, G, H, J, M, N, O, P, Q, R and mixtures of non-dihydrate forms, and at least one pharmaceutically acceptable excipient;
• b) compressing the blend to produce a compressed material;
• c) milling the compressed material to produce granules;
• d) processing the granules into a capsule.