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US 2003/0228346 A1Published application
Sustained release of superoxide dismutase mimics from implantable or insertable medical devices
AssigneeSciMed Life Systems, Inc.
InventorRobert A. Herrmann
Life of this patent
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Abstract
An implantable or insertable medical device is provided which comprises (a) a superoxide dismutase mimic and (b) a polymeric release region. Upon administration to a patient, the polymeric release region controls the release of the superoxide dismutase mimic, which is beneficially selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic. Also provided is a method of making an implantable or insertable medical device.
Claims24
An implantable or insertable medical device comprising:
- a superoxide dismutase mimic selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic;
- and
- a polymeric release region that controls the release of said superoxide dismutase mimic upon administration to a patient.
A method of forming an implantable or insertable medical device comprising:
- providing a solution or dispersion comprising a superoxide dismutase mimic selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic, a polymer and a solvent;
- contacting said solution or dispersion with a medical device;
- and
- removing said solvent to form a superoxide dismutase mimic-containing polymer matrix on said medical device.
1 more element
Dependencies are inferred from the claim text.