Osteogenic devices
AssigneeStryker Biotech
InventorsHermann Oppermann, Thangavel Kuberasampath, David C. Rueger, Engin Ozkaynak
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Abstract
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Claims80
An osteogenic device for implantation in a mammal, said device comprising:
- a biocompatible, in vivo biodegradable matrix defining pores of a dimension sufficient to permit influx, proliferation and differentiation of migratory progenitor cells from the body of said mammal;
- and
- a protein, produced by expression of recombinant DNA in a host cell, comprising one or more polypeptide chains, each of which has an amino acid sequence sufficiently duplicative of the sequence of COP-5 or COP-7 such that said protein is capable of inducing endochondral bone formation in association with said matrix when implanted in a mammal.
A device for implantation in a mammal, said device comprising:
- a biocompatible, in vivo biodegradable matrix defining pores of a dimension sufficient to permit influx, proliferation and differentiation of migratory progenitor cells from the body of said mammal;
- and
- a protein, produced by expression of recombinant DNA in a host cell, comprising one or more polypeptide chains, each of which has less than about 200 amino acids, in a sequence sufficiently duplicative of the sequence of COP-5 or COP-7 such that said protein is capable or inducing cartilage formation in association with said matrix when implanted in a mammal.
Osteogenic protein, produced by expression of recombinant DNA in a host cell, capable of inducing endochondral bone formation in association with a matrix when implanted in a mammal.
A protein, produced by expression of recombinant DNA in a host cell, comprising one or more polypeptide chains less than about 200 amino acids long in a sequence sufficiently duplicative of the sequence of COP-5 or COP-7 such that said protein is capable of inducing cartilage formation in association with a matrix when implanted in a mammal.
A DNA sequence encoding an amino acid sequence sufficiently duplicative of that of the sequence encoded by the gene of FIG. 1A_ such that said encoded sequence induces bone or cartilage formation when implanted in a mammal in association with a matrix.
A biocompatible, in vivo biodegradable deglycosylated collagenous matrix defining pores of dimensions sufficient to permit influx, proliferation, and differentiation of migratory progenitor cells from the body of a mammal.
An osteogenic device for implantation in a mammal, said device comprising:
- a biocompatible, in vivo biodegradable matrix defining pores of a dimension sufficient to permit influx, proliferation and differentiation of migratory progenitor cells from the body of said mammal;
- and
- substantially pure osteogenic protein capable of inducing endochondral bone formation in said mammal disposed in said matrix and accessible to said cells.
Dependencies are inferred from the claim text.