US 2003/0228301 A1Published application

Novel human proteins, polynucleotides encoding them and methods of using the same

OwnerLi Li, Katarzyna Furtak +24inventors

InventorsLi Li, Katarzyna Furtak, Amanda Perna, Meera Patturajan, Richard A. Shimkets, Xiaojia Sasha Guo, Stacie J. Casman, Catherine E. Burgess, Uriel M. Malyankar, Velizar T. Tchernev, Corine A. Vernet, Kimberly A. Spytek, Michele Agee, Luca Rastelli, Suresh G. Shenoy, William M. Grosse, John P. Alsobrook II, Denise M. Lepley, Valerie Gerlach, Schlomit R. Edinger, John R. MacDougall, John A. Peyman, Erik Gunther, David J. Stone, Karen Ellerman, Esha A. Gangolli

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Abstract

Disclosed are novel polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Claims41

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

5 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31;
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 29, and/or 31, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/004,378Filed 24 Oct 2001
Priority: 24 Oct 2000
Published: 11 Dec 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07K 14/47
From vertebrates: from mammals
A61K 38/00
Medicinal preparations containing peptides
C07K
Peptides
A61K
Medicines and medical preparations

Family

Application60/242,882Us provisional application · filed 24 Oct 2000
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Application60/273,047Us provisional application · filed 2 Mar 2001
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Application60/316,509Us provisional application · filed 31 Aug 2001
US 2003/0228301 A1This patent

From the US filing history. Foreign family members aren’t listed.