Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
OwnerAladar Szalay, A. Douglas Willinventors
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Abstract
A method for using a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent protein for the preparation of a diagnostic composition for diagnosis and/or visualization of wounded or inflamed tissue or a disease associated therewith. Further, the microorganism or cell may additionally contain an expressible DNA sequence encoding a protein suitable for therapy, e.g. an enzyme causing cell death or digestion of debris.
Claims32
A diagnostic composition for diagnosis and/or visualization of wounded or inflamed tissue or a disease associated therewith, comprising:
- a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal.
A pharmaceutical composition for the treatment of wounded or inflamed tissue or a disease associated therewith, comprising:
- a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal and at least one expressible DNA sequences encoding (a) protein(s) suitable for the therapy of wounded or inflamed tissue or a disease associated therewith.
A method for diagnosis and/or visualization of wounded or inflamed tissue or a disease associated therewith, the method comprising:
- a) introducing into a microoganism or cell a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal;
- b) introducing the microoganism or cell into a subject;
- and
- c) monitoring the detectable protein or a protein capable of inducing a detectable signal in the subject.
Dependencies are inferred from the claim text.